{"id":"W3010231504","doi":"10.1158/1538-7445.sabcs19-pd3-03","title":"Abstract PD3-03: Impact of the breast cancer polygenic risk score on preventive endocrine therapy adherence and endocrine therapy usage on quality of life - The Genetic Risk Estimate (GENRE) trial","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"Medicine; Breast cancer; Odds ratio; Internal medicine; Risk assessment; Gynecology; Single-nucleotide polymorphism; Cancer; Oncology; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001510795,0.0005453754,0.001045253,0.0001812659,0.000244716,0.0006570873,0.0005452252,0.0008369451,0.00508444],"category_scores_gemma":[0.002196438,0.0001546259,0.001514479,0.0003481788,0.0002978534,0.0003892053,0.0003526969,0.002150337,0.0003854996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003734704,"about_ca_system_score_gemma":0.0005171633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267478,"about_ca_topic_score_gemma":0.001176206,"domain_scores_codex":[0.999355,0.000410013,0.00004167886,0.0001024657,0.00004904604,0.00004170248],"domain_scores_gemma":[0.9992148,0.0002351627,0.0002140362,0.000102778,0.00004360485,0.0001896679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.884491,0.003467166,0.04038889,0.001481754,0.006245052,0.0001024912,0.00005602715,0.001345183,0.001860238,0.0005055972,0.005595528,0.05446099],"study_design_scores_gemma":[0.7313514,0.08267831,0.1605102,0.0004364065,0.01004599,0.0003309712,0.00008045002,0.006101654,0.001256494,0.002395584,0.004751794,0.00006078352],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822542,0.006004433,0.0007190694,0.00139987,0.0001858917,0.0008296701,0.004117244,0.0001147239,0.004374888],"genre_scores_gemma":[0.9926317,0.0009317963,0.0007790333,0.0007875193,0.0001676028,0.0006980862,0.002534217,0.00001451051,0.00145563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00508444,"threshold_uncertainty_score":0.01700908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1002407002893074,"score_gpt":0.4462595018084889,"score_spread":0.3460188015191815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}