{"id":"W3010272507","doi":"10.1016/j.ccell.2020.02.002","title":"Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas","year":2020,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network; SickKids Foundation; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Fonds de Recherche du Québec - Santé; Bayer; Nederlandse Federatie van Universitair Medische Centra; Fundação de Amparo à Pesquisa do Estado de São Paulo; Brain Tumour Charity; AbbVie; Novartis Pharma; Canada Foundation for Innovation; Cure Starts Now Foundation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Merck KGaA; ZonMw; Koninklijke Nederlandse Akademie van Wetenschappen; Boehringer Ingelheim; Takeda Pharmaceuticals U.S.A.; Pfizer; Canadian Institutes of Health Research; Innovative Medicines Initiative; Cancer Genomics Centre; Heart Foundation; Cancer Research Society; Genome Canada; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Carcinogenesis; Glioma; Mutant; Biology; Cancer research; Medicine; Neuroscience; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001171616,0.0002649929,0.0002251657,0.0002657877,0.0001127177,0.0002827704,0.0002118522,0.0001882553,0.0008649934],"category_scores_gemma":[0.000105139,0.0001087706,0.0001541958,0.0001693597,0.0001739537,0.0001535275,0.0001240495,0.0005305184,0.0002373853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003398765,"about_ca_system_score_gemma":0.0002705583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293576,"about_ca_topic_score_gemma":0.00351727,"domain_scores_codex":[0.9999061,0.00001680801,0.000009360315,0.00001380689,0.00002624249,0.00002770753],"domain_scores_gemma":[0.999926,0.00001791239,0.00002020086,0.000008757634,0.000006112671,0.0000210912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001153934,0.00006656954,0.0003031266,0.00002423955,0.000005035503,0.00009640177,0.00001892035,0.0002834516,0.9951543,0.0002674978,0.00009028479,0.003574838],"study_design_scores_gemma":[0.0000343548,0.0006819913,0.003678271,0.000005148866,0.00001310743,0.0006200941,0.00003284348,0.001336852,0.9903612,0.00006557758,0.003166326,0.000004168689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957427,0.00102944,0.001392641,0.00008395914,0.00001135855,0.00001918401,0.0002020189,0.00009021937,0.001428501],"genre_scores_gemma":[0.9957584,0.0009315872,0.001738061,0.00002526872,0.000005150368,0.00001534788,0.0002817793,0.00002375661,0.001220691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293576,"threshold_uncertainty_score":0.002893627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585033835028226,"score_gpt":0.2566999957637245,"score_spread":0.2408496574134422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}