{"id":"W3010272507","doi":"10.1016/j.ccell.2020.02.002","title":"Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas","year":2020,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network; SickKids Foundation; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Pharmaceuticals; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Fonds de Recherche du Québec - Santé; Bayer; Nederlandse Federatie van Universitair Medische Centra; Fundação de Amparo à Pesquisa do Estado de São Paulo; Brain Tumour Charity; AbbVie; Novartis Pharma; Canada Foundation for Innovation; Cure Starts Now Foundation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Merck KGaA; ZonMw; Koninklijke Nederlandse Akademie van Wetenschappen; Boehringer Ingelheim; Takeda Pharmaceuticals U.S.A.; Pfizer; Canadian Institutes of Health Research; Innovative Medicines Initiative; Cancer Genomics Centre; Heart Foundation; Cancer Research Society; Genome Canada; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Carcinogenesis; Glioma; Mutant; Biology; Cancer research; Medicine; Neuroscience; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002871818,0.0001905064,0.0002967402,0.0001021883,0.00003512656,0.0000196863,0.00008447708,0.000065968,0.0003814837],"category_scores_gemma":[0.00001577709,0.0001650331,0.0000916506,0.0004892849,0.00000868096,0.00004935886,0.00004542244,0.00008574999,0.0001836859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903675,"about_ca_system_score_gemma":0.0001204942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004465024,"about_ca_topic_score_gemma":0.0003675298,"domain_scores_codex":[0.9987957,0.00002519062,0.0002481916,0.0003971929,0.0002447106,0.0002889808],"domain_scores_gemma":[0.9993161,0.00003106437,0.00007640837,0.0001761673,0.00005420604,0.0003460667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003598494,0.001003724,0.8457751,0.0003708152,0.00003237407,0.0007402138,0.00278174,0.0003549524,0.1415514,0.00001133342,0.00514678,0.001871684],"study_design_scores_gemma":[0.00391563,0.0004523994,0.4912413,0.00003748679,0.0002963789,0.000002064269,0.0001779855,0.0003159868,0.501112,0.00001001914,0.002188112,0.0002506445],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940276,0.002250939,0.00003083764,0.001695823,0.000417733,0.0005796808,0.00003242247,0.00004340784,0.0009216127],"genre_scores_gemma":[0.9971982,0.0008935175,0.0001197368,0.00070126,0.0007817827,0.0001939326,0.00002627011,0.00003058306,0.00005476812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3595606,"threshold_uncertainty_score":0.6729853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585033835028226,"score_gpt":0.2566999957637245,"score_spread":0.2408496574134422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}