{"id":"W3010276544","doi":"10.1016/j.cell.2020.01.019","title":"Blocking HbS Polymerization in SCD","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Hemolysis; Biology; Polymerization; Deoxygenation; Point mutation; Hemoglobin; Mutation; Gene; Immunology; Molecular biology; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001969745,0.00004376274,0.00007915425,0.00002620574,0.0000150959,0.000004055329,0.00002218936,0.00005426013,0.0001383283],"category_scores_gemma":[0.00002008805,0.00003807509,0.0000216241,0.0001881095,0.00001213911,0.00001635481,0.00001137757,0.0001018879,0.0000896709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000092131,"about_ca_system_score_gemma":0.00002769733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001629052,"about_ca_topic_score_gemma":6.622357e-7,"domain_scores_codex":[0.999653,0.000007596788,0.00008945828,0.00009240171,0.00006005675,0.00009744356],"domain_scores_gemma":[0.9998491,0.000005128152,0.0000161965,0.00005157146,0.000007565322,0.0000704015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002520764,0.0004010619,0.09546368,0.0005815607,0.00003005731,0.0004082577,0.009542226,0.0006050823,0.8560181,0.0001941446,0.006224053,0.0302797],"study_design_scores_gemma":[0.01741704,0.001238737,0.04714685,0.000607663,0.0002287067,0.00005342813,0.007441164,0.05164006,0.6972094,0.000151824,0.1759164,0.0009488151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454868,0.00116346,0.0002163792,0.00567469,0.00007786464,0.0001263919,6.052021e-7,0.00004814215,0.04720563],"genre_scores_gemma":[0.9972857,0.0001113023,0.00007843137,0.00209045,0.00005062082,0.000001133325,0.000009160385,0.000008849146,0.0003643424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1696923,"threshold_uncertainty_score":0.1552657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040237029502125,"score_gpt":0.2183137224024781,"score_spread":0.2079113521074568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}