{"id":"W3010276544","doi":"10.1016/j.cell.2020.01.019","title":"Blocking HbS Polymerization in SCD","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Hemolysis; Biology; Polymerization; Deoxygenation; Point mutation; Hemoglobin; Mutation; Gene; Immunology; Molecular biology; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005826643,0.000228393,0.0003762785,0.0002990276,0.0002504118,0.0004155778,0.0002589488,0.0004347722,0.002604035],"category_scores_gemma":[0.0008322662,0.0001388918,0.0001680215,0.0001461262,0.000286507,0.0001667871,0.0002371448,0.0009503727,0.0005614584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002866247,"about_ca_system_score_gemma":0.000368394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004583828,"about_ca_topic_score_gemma":0.000511594,"domain_scores_codex":[0.999756,0.0000904047,0.00002388064,0.00001896417,0.00005331492,0.00005751044],"domain_scores_gemma":[0.9996073,0.0001647306,0.00005634729,0.0000405072,0.00002904931,0.0001020277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0163972,0.004342085,0.02505957,0.0009450287,0.0001958837,0.001872874,0.0002965517,0.001977055,0.6561251,0.01059685,0.01171662,0.2704752],"study_design_scores_gemma":[0.002428745,0.01816424,0.04076321,0.0002308125,0.0003653638,0.007799959,0.0001030062,0.005838009,0.845155,0.003412504,0.07569895,0.00004010163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536861,0.023208,0.004710596,0.001780061,0.0007306469,0.0001322908,0.0001542983,0.0003549078,0.01524293],"genre_scores_gemma":[0.9928862,0.00304639,0.001364732,0.0004010239,0.0002328966,0.00003552345,0.0001434819,0.00001939871,0.0018703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002604035,"threshold_uncertainty_score":0.008711398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040237029502125,"score_gpt":0.2183137224024781,"score_spread":0.2079113521074568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}