{"id":"W3010277177","doi":"10.1101/2020.03.04.976555","title":"STK32A is a dual-specificity AGC kinase with a preference for acidic substrates","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Ministry of Economic Development and Innovation; Genome Canada; Pfizer","keywords":"Threonine; Kinase; Subfamily; Serine; MAP2K7; Biochemistry; SH3 domain; Biology; Protein kinase domain; c-Raf; Protein-Serine-Threonine Kinases; Phosphorylation; Protein kinase A; Cyclin-dependent kinase 2; Receptor tyrosine kinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008669742,0.0003481924,0.000243683,0.0002123317,0.0001889163,0.0002724857,0.0001158129,0.00028246,0.001383913],"category_scores_gemma":[0.0001217208,0.0001257704,0.0002004058,0.0002089345,0.0002727367,0.000107223,0.0001704377,0.0003298966,0.000684703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002951985,"about_ca_system_score_gemma":0.0002088333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006162334,"about_ca_topic_score_gemma":0.0004908787,"domain_scores_codex":[0.9999037,0.00001244503,0.000006464059,0.00002535436,0.00003438192,0.00001776193],"domain_scores_gemma":[0.9999216,0.000008991758,0.00002086794,0.000006138617,0.000009163197,0.00003326122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001445579,0.0000127008,0.000753869,0.00001649659,0.000005765994,0.0002861594,0.000006528931,0.0001551704,0.9974902,0.0001567654,0.000107395,0.0008644687],"study_design_scores_gemma":[0.00008272853,0.0003097618,0.03805206,0.0000103972,0.00001724244,0.007588426,0.00005521645,0.005388343,0.9397681,0.0004511282,0.00825807,0.00001849234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966879,0.0006507599,0.00112644,0.00009677721,0.00002193713,0.00001359149,0.0003878547,0.00004030398,0.0009743616],"genre_scores_gemma":[0.9957083,0.0001764712,0.00141797,0.00003671623,0.000007706592,0.00001103246,0.001025652,0.00001083125,0.001605279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383913,"threshold_uncertainty_score":0.004629612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854882056446323,"score_gpt":0.2311068528115748,"score_spread":0.2025580322471116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}