{"id":"W3010322897","doi":"10.1074/mcp.ra119.001909","title":"Human Hepatocyte Nuclear Factor 4-α Encodes Isoforms with Distinct Transcriptional Functions","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Institute of Nutrition, Metabolism and Diabetes; Institute of Cancer Research; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Gene isoform; Alternative splicing; Biology; Exon; Proteome; Transcription factor; Promoter; RNA splicing; Transcriptome; Nuclear receptor; Hepatocyte nuclear factor 4; Cell biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596587,0.0002540888,0.0001975469,0.0003856159,0.0001441406,0.0003593897,0.0001219107,0.0001279099,0.0009206442],"category_scores_gemma":[0.0001861004,0.0001651278,0.0002749845,0.0005423778,0.0001462504,0.000149784,0.0001414318,0.000229847,0.0007740876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843707,"about_ca_system_score_gemma":0.0002059296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162836,"about_ca_topic_score_gemma":0.001376201,"domain_scores_codex":[0.9998333,0.00001958504,0.0000135412,0.00004778385,0.00005390908,0.00003175329],"domain_scores_gemma":[0.9998389,0.00002614895,0.00005558963,0.00002478757,0.00003469284,0.00001988196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003937021,0.00001320337,0.004759716,0.00004975601,0.00002046951,0.0001735566,0.00004246787,0.0001103155,0.9853647,0.0001500654,0.0001184538,0.008803548],"study_design_scores_gemma":[0.00007024924,0.0005686058,0.1612015,0.00003947162,0.0001368228,0.003852062,0.0002270346,0.003172015,0.7975557,0.0008605471,0.03228011,0.00003583234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802409,0.003417188,0.01036595,0.000115554,0.00003529523,0.00003015054,0.003958254,0.000174659,0.001662065],"genre_scores_gemma":[0.9665404,0.002262875,0.01185289,0.000137612,0.00003184857,0.00003208577,0.01348153,0.00005795943,0.005602814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001162836,"threshold_uncertainty_score":0.003079891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144446981182865,"score_gpt":0.2016220540230089,"score_spread":0.1871773559047224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}