{"id":"W3010322897","doi":"10.1074/mcp.ra119.001909","title":"Human Hepatocyte Nuclear Factor 4-α Encodes Isoforms with Distinct Transcriptional Functions","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Institute of Nutrition, Metabolism and Diabetes; Institute of Cancer Research; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Gene isoform; Alternative splicing; Biology; Exon; Proteome; Transcription factor; Promoter; RNA splicing; Transcriptome; Nuclear receptor; Hepatocyte nuclear factor 4; Cell biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0000667058,0.0002920281,0.0002675572,0.00007434632,0.0004571083,0.00005958846,0.0002104563,0.000226262,0.003307317],"category_scores_gemma":[0.00002251525,0.0002504323,0.0002004204,0.0001637331,0.0001655591,0.0001858559,0.00004749724,0.0005738636,0.001445863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007035891,"about_ca_system_score_gemma":0.00004974843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004759574,"about_ca_topic_score_gemma":0.000005607324,"domain_scores_codex":[0.9986714,0.0001202496,0.0003316414,0.0004406444,0.00008433974,0.0003517479],"domain_scores_gemma":[0.9994284,0.000008929808,0.0001347947,0.0002642499,0.00009771711,0.00006590091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003334615,0.0001123407,0.0003046526,0.00002784163,0.0001888512,0.00001964346,0.0004238218,0.00004619936,0.9963527,0.001045454,0.0009169386,0.0002280516],"study_design_scores_gemma":[0.001429658,0.0007682723,0.0007245728,0.00002218912,0.00007580443,0.00005360285,0.0002621576,0.0001607584,0.8792524,0.00003216105,0.1168499,0.0003684243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447548,0.0003156977,0.05088611,0.0006660124,0.0005613726,0.0006329447,0.00002967788,0.0002370573,0.001916283],"genre_scores_gemma":[0.9952117,0.000005589816,0.0004083444,0.0007811172,0.0000543253,0.00005479632,0.000466923,0.0000649473,0.002952309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1171003,"threshold_uncertainty_score":0.9999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144446981182865,"score_gpt":0.2016220540230089,"score_spread":0.1871773559047224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}