{"id":"W3010327104","doi":"10.1200/jco.2007.25.18_suppl.4033","title":"Final results of CONFIRM 2: A multinational, randomized, double-blind, phase III study in 2nd line patients (pts) with metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sudbury Regional Hospital","funders":"","keywords":"Medicine; Internal medicine; Colorectal cancer; Clinical endpoint; Irinotecan; Gastroenterology; Placebo; Bevacizumab; Adverse effect; Interim analysis; Phases of clinical research; Cancer; Oncology; Randomized controlled trial; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007890206,0.0002925978,0.003368574,0.000356508,0.00008461118,0.00001230961,0.0001233173,0.0001813927,0.00009676998],"category_scores_gemma":[0.005072551,0.0001673632,0.0002864572,0.0003674349,0.000504503,0.0001410223,0.00008149385,0.0007886282,7.913856e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003533344,"about_ca_system_score_gemma":0.00140508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007571738,"about_ca_topic_score_gemma":0.01735056,"domain_scores_codex":[0.9939938,0.0005642538,0.004023321,0.0003706248,0.00069832,0.0003497195],"domain_scores_gemma":[0.9859263,0.009541302,0.002939393,0.0001277088,0.001160078,0.0003052129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.847251,0.01377735,0.0771781,0.00004277928,0.001980364,0.0008325232,0.001769468,0.00003511702,0.00001355436,0.000006452342,0.000188648,0.05692466],"study_design_scores_gemma":[0.8099039,0.05396872,0.1315494,0.0003005031,0.001577417,0.00009944694,0.001236009,0.0001585497,0.00007010595,0.0000164051,0.0009747767,0.0001447071],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941017,0.0005920026,0.0000530398,0.001279064,0.0005972942,0.002472908,0.00003291212,0.000007110487,0.000863975],"genre_scores_gemma":[0.9969943,0.0007737565,0.001247228,0.0002365592,0.0003486928,0.00008584889,0.000009852024,0.0000214889,0.0002822722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05677996,"threshold_uncertainty_score":0.968202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1797229326648753,"score_gpt":0.5009832734707488,"score_spread":0.3212603408058735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}