{"id":"W3010327104","doi":"10.1200/jco.2007.25.18_suppl.4033","title":"Final results of CONFIRM 2: A multinational, randomized, double-blind, phase III study in 2nd line patients (pts) with metastatic colorectal cancer (mCRC) receiving FOLFOX4 and PTK787/ZK 222584 (PTK/ZK) or placebo","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sudbury Regional Hospital","funders":"","keywords":"Medicine; Internal medicine; Colorectal cancer; Clinical endpoint; Irinotecan; Gastroenterology; Placebo; Bevacizumab; Adverse effect; Interim analysis; Phases of clinical research; Cancer; Oncology; Randomized controlled trial; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003441012,0.001720443,0.002779374,0.000360748,0.0006146529,0.001186378,0.001170596,0.002013736,0.006104629],"category_scores_gemma":[0.002312044,0.001007773,0.002234529,0.0003190171,0.0009081725,0.001014709,0.000497774,0.002862873,0.001250535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009015369,"about_ca_system_score_gemma":0.002125247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008032198,"about_ca_topic_score_gemma":0.003167513,"domain_scores_codex":[0.9992821,0.0004267278,0.00003768491,0.0000860306,0.00006691136,0.0001006424],"domain_scores_gemma":[0.9986073,0.0002765638,0.0003764558,0.0001836751,0.0001171854,0.0004388771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.948305,0.0191219,0.002582344,0.0005003613,0.001197412,0.0001119561,0.0001313089,0.0005605915,0.009886837,0.0001083814,0.002425488,0.01506854],"study_design_scores_gemma":[0.8723903,0.1192126,0.004779429,0.00002779167,0.0006107636,0.00007313964,0.0000227722,0.0002147293,0.0009398279,0.00008364081,0.001625499,0.00001951517],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812868,0.002931386,0.0009879587,0.001119268,0.0003059004,0.00766081,0.003281516,0.0001897803,0.002236561],"genre_scores_gemma":[0.9653499,0.002430779,0.004405012,0.002550387,0.0004872298,0.01264211,0.005180465,0.00008389767,0.006870165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006104629,"threshold_uncertainty_score":0.02042198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1797229326648753,"score_gpt":0.5009832734707488,"score_spread":0.3212603408058735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}