{"id":"W3010351109","doi":"10.1038/s41598-020-61107-x","title":"Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis transmembrane conductance regulator; Endoplasmic reticulum; Endoplasmic-reticulum-associated protein degradation; Cell biology; Chaperone (clinical); Protein folding; Co-chaperone; Mutant; Chemistry; Transmembrane domain; Transmembrane protein; Cytosol; Cystic fibrosis; Biology; Unfolded protein response; Biochemistry; Hsp90; Membrane; Genetics; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887438,0.0002941629,0.0003360206,0.0002997052,0.0002257252,0.0002520661,0.0001749484,0.0002868625,0.001404147],"category_scores_gemma":[0.0003421251,0.0001693986,0.0002321443,0.0002439098,0.0002048185,0.0001534394,0.0003913331,0.0002505558,0.00035866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236246,"about_ca_system_score_gemma":0.0001933553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007995032,"about_ca_topic_score_gemma":0.001736152,"domain_scores_codex":[0.9996648,0.00007561208,0.00001299756,0.00005371521,0.0001080837,0.00008480565],"domain_scores_gemma":[0.9998434,0.00003518251,0.00002566718,0.00001367633,0.00002920259,0.0000529333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001484245,0.000031681,0.0005454168,0.00003581351,0.000009664426,0.00003405078,0.00001494086,0.0001461185,0.9972613,0.00004690537,0.00006396016,0.001661781],"study_design_scores_gemma":[0.00002301628,0.0007685084,0.01746201,0.00001459737,0.00003088074,0.0005655735,0.00007726943,0.001840925,0.9764048,0.00007053815,0.002727953,0.00001393394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949386,0.002142225,0.001616734,0.00005644114,0.00001774278,0.00002142076,0.0001239879,0.00003326469,0.001049478],"genre_scores_gemma":[0.9970512,0.0005632232,0.001008938,0.00008122605,0.000008976934,0.00001712276,0.000233924,0.00001007046,0.001025187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404147,"threshold_uncertainty_score":0.004697323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04705066142652913,"score_gpt":0.3477232978101829,"score_spread":0.3006726363836538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}