{"id":"W3010370531","doi":"10.1002/hep.31205","title":"Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial","year":2020,"lang":"en","type":"article","venue":"Hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":321,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; Muscular Dystrophy Canada; University of Toronto","funders":"","keywords":"Nonsteroidal; Agonist; Medicine; Randomized controlled trial; Internal medicine; Pharmacology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492101,0.0002495134,0.002189315,0.0001001469,0.0000391968,0.00001413694,0.00006667096,0.0001020226,0.000288967],"category_scores_gemma":[0.0002777599,0.0001569653,0.0003330993,0.0001533201,0.0001451664,0.00003414497,0.00002790857,0.0001480005,0.00008071445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006378992,"about_ca_system_score_gemma":0.000272197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000502954,"about_ca_topic_score_gemma":0.00002782325,"domain_scores_codex":[0.9981217,0.0003427167,0.0005772038,0.0003904438,0.0002494378,0.000318461],"domain_scores_gemma":[0.9988278,0.0004008069,0.0001783389,0.0002002692,0.0000916936,0.000301054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.82447,0.003836259,0.1696893,0.00003215532,0.0006302195,0.0005120295,0.0002521144,4.456487e-7,0.000003996693,0.0001003359,0.0002324747,0.0002406888],"study_design_scores_gemma":[0.9905101,0.003958453,0.002648088,0.00004154139,0.001264777,0.000006863402,0.00001843158,0.00117493,0.00002936152,0.00001579141,0.0001882524,0.0001433984],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98853,0.0002670838,0.0000267247,0.002536752,0.0001815585,0.007364401,0.00002375772,0.00004031325,0.001029347],"genre_scores_gemma":[0.9956797,0.00002299998,0.0001066087,0.002656326,0.00008872016,0.001287245,0.00009894354,0.00002293253,0.00003647172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1670412,"threshold_uncertainty_score":0.6400859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013133113772877,"score_gpt":0.2621497445796389,"score_spread":0.2490166308067619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}