{"id":"W3010448637","doi":"10.1200/jop.19.00506","title":"Patterns of Ruxolitinib Therapy Failure and Its Management in Myelofibrosis: Perspectives of the Canadian Myeloproliferative Neoplasm Group","year":2020,"lang":"en","type":"review","venue":"JCO Oncology Practice","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Memorial University of Newfoundland; Juravinski Cancer Centre; University of British Columbia; Windsor Regional Hospital; University of Calgary; McMaster University; St. Paul's Hospital; Princess Margaret Cancer Centre; Dalhousie University; University of Toronto","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Medicine; Myeloproliferative neoplasm; Splenectomy; Clinical trial; Extramedullary hematopoiesis; Internal medicine; Transplantation; Oncology; Intensive care medicine; Surgery; Stem cell; Bone marrow; Spleen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001756559,0.0003929042,0.0004811076,0.003117621,0.00113764,0.001594915,0.0008892615,0.0008035869,0.001885086],"category_scores_gemma":[0.004846824,0.0001495997,0.0003748966,0.003365472,0.00105135,0.0009525011,0.0006791367,0.001088199,0.0003095793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009561431,"about_ca_system_score_gemma":0.02996082,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.5535157,"about_ca_topic_score_gemma":0.6953663,"domain_scores_codex":[0.9992633,0.0001068398,0.00006538645,0.00006386598,0.0003848157,0.0001157927],"domain_scores_gemma":[0.995986,0.000313805,0.0004078074,0.0000487857,0.00267049,0.0005730344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001857607,0.00005267532,0.04724117,0.001898409,0.000114469,0.00111113,0.001017378,0.0004254834,0.0006230311,0.005095914,0.1340589,0.8081757],"study_design_scores_gemma":[0.00007178752,0.0001436263,0.1644059,0.00694413,0.0003322573,0.008566576,0.002786029,0.000896478,0.0004976673,0.00386478,0.8113179,0.0001728916],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02124628,0.8422132,0.001175448,0.1051141,0.002107392,0.00006213329,0.000619411,0.00006435099,0.02739774],"genre_scores_gemma":[0.1313619,0.8492095,0.003654874,0.008108687,0.003080318,0.00005621315,0.0009288581,0.00003730812,0.00356237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4464843,"threshold_uncertainty_score":0.8982274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04523296266087844,"score_gpt":0.3649477534339695,"score_spread":0.3197147907730911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}