{"id":"W3010489206","doi":"","title":"A pharmaceutical approach to achieve synergy in vivo: A fixed ratio formulation of Irinotecan and Floxuridine for treatment of colorectal cancer","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Irinotecan; Floxuridine; In vivo; Pharmacology; Colorectal cancer; Drug; Chemistry; Cancer; Medicine; Internal medicine; Fluorouracil; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346768,0.0006166811,0.000402571,0.0004779862,0.0001482394,0.0004754703,0.0004199474,0.0005281347,0.0008848964],"category_scores_gemma":[0.0001871653,0.0002530164,0.0003673168,0.000200573,0.0002776614,0.000380447,0.000289055,0.0007179435,0.000308019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005942258,"about_ca_system_score_gemma":0.0004240115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003655191,"about_ca_topic_score_gemma":0.001010458,"domain_scores_codex":[0.9997857,0.00004769717,0.00001677061,0.00005136628,0.00006996089,0.00002840682],"domain_scores_gemma":[0.9999169,0.00001281227,0.0000333445,0.000007349472,0.00001451831,0.00001505861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009091246,0.0001118234,0.00009295928,0.00007021064,0.00001251131,0.00003237138,0.00001068206,0.000259353,0.9947155,0.0001566525,0.00004259767,0.004404303],"study_design_scores_gemma":[0.00007419735,0.002173295,0.0009718115,0.00001177668,0.00004695218,0.0004236765,0.00001127279,0.001409004,0.9912809,0.0000407531,0.003546468,0.00000993147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960521,0.005303781,0.02853592,0.0005956339,0.00007739524,0.0004973868,0.0002348898,0.000190245,0.00404378],"genre_scores_gemma":[0.9645745,0.002023138,0.0312712,0.0001749282,0.00002544757,0.0001449918,0.0001993856,0.00002434155,0.001562064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008848964,"threshold_uncertainty_score":0.004311442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08043896976769893,"score_gpt":0.4147457075727549,"score_spread":0.334306737805056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}