{"id":"W3010500731","doi":"10.1007/s00401-020-02131-z","title":"DNA methylation age acceleration is associated with ALS age of onset and survival","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Sunnybrook Health Science Centre; Sunnybrook Hospital; Occupational Cancer Research Centre; Health Sciences Centre; Canada Research Chairs; University of Toronto","funders":"Consortium canadien en neurodégénérescence associée au vieillissement; Fondation Brain Canada; ALS Society of Canada","keywords":"DNA methylation; Medicine; Age of onset; Biology; Methylation; Genetics; Oncology; DNA; Internal medicine; Gene; Gene expression; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002026258,0.0001223293,0.0001709761,0.00002063192,0.00005364829,0.00002561794,0.00007322603,0.0001139171,0.00001219279],"category_scores_gemma":[0.0004258791,0.0001008012,0.00003472732,0.0001066677,0.0000707788,0.000005817441,0.00006999777,0.00007392378,0.000001005779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002881232,"about_ca_system_score_gemma":0.00001517095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002063621,"about_ca_topic_score_gemma":0.000006405442,"domain_scores_codex":[0.9990326,0.0002219958,0.0001889924,0.0003101519,0.0001263289,0.0001199111],"domain_scores_gemma":[0.9995236,0.00004040837,0.0001523501,0.0001530648,0.00006978077,0.00006081583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006284087,0.0000287468,0.008341512,0.00000636384,0.00001311094,0.00004020453,0.0001424006,0.00001494717,0.9906362,0.00000797428,0.00004712108,0.000658636],"study_design_scores_gemma":[0.0004654981,0.001228639,0.3067823,0.000006007478,0.00003323474,0.000003633186,0.00002421307,0.00007749454,0.6894224,0.00008902219,0.001704788,0.0001627029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976953,0.0001526184,0.0008574913,0.0004021236,0.00003058836,0.0001483557,0.00003502924,0.00001496249,0.0006635789],"genre_scores_gemma":[0.9985535,0.0002804944,0.0002935962,0.0004649847,0.00004589753,0.000005025755,0.0002947932,0.00001527713,0.00004650065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3012137,"threshold_uncertainty_score":0.4110553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03974264127831263,"score_gpt":0.2632055430188692,"score_spread":0.2234629017405566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}