{"id":"W3010500731","doi":"10.1007/s00401-020-02131-z","title":"DNA methylation age acceleration is associated with ALS age of onset and survival","year":2020,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ted Rogers Centre for Heart Research; Sunnybrook Health Science Centre; Sunnybrook Hospital; Occupational Cancer Research Centre; Health Sciences Centre; Canada Research Chairs; University of Toronto","funders":"Consortium canadien en neurodégénérescence associée au vieillissement; Fondation Brain Canada; ALS Society of Canada","keywords":"DNA methylation; Medicine; Age of onset; Biology; Methylation; Genetics; Oncology; DNA; Internal medicine; Gene; Gene expression; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056814,0.0002456204,0.0003202195,0.00051794,0.0002197486,0.0002518369,0.0001580971,0.0003837009,0.005950511],"category_scores_gemma":[0.001236172,0.0001526532,0.0003190883,0.0003861319,0.0001545666,0.0002004858,0.0002824468,0.000360121,0.0004939497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683968,"about_ca_system_score_gemma":0.0001328828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002333945,"about_ca_topic_score_gemma":0.001691674,"domain_scores_codex":[0.9998597,0.00002105347,0.00001442934,0.0000576812,0.00002157548,0.00002550917],"domain_scores_gemma":[0.9993711,0.0000960468,0.0003101265,0.00003908509,0.00005779217,0.0001258646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003404088,0.0000730359,0.9345044,0.0001021493,0.0003306943,0.001235188,0.0004232851,0.0002764478,0.04198301,0.000212783,0.0005922208,0.0168627],"study_design_scores_gemma":[0.000007288666,0.0001034156,0.9964617,0.00001543632,0.00007491033,0.001333676,0.00007018608,0.0002515379,0.001070686,0.0001788297,0.0004237211,0.000008702517],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980715,0.0006173314,0.0002306157,0.00005562822,0.00001149453,0.000004033078,0.0004431052,0.00001467138,0.0005515983],"genre_scores_gemma":[0.9987444,0.0001935228,0.0001404584,0.00001046787,0.000008641494,0.00000372349,0.0002066505,0.000006239949,0.0006859609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005950511,"threshold_uncertainty_score":0.01990646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03974264127831263,"score_gpt":0.2632055430188692,"score_spread":0.2234629017405566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}