{"id":"W3010522503","doi":"10.1158/1538-7445.sabcs19-ot1-08-07","title":"Abstract OT1-08-07: CONTESSA 2: A multinational, multicenter, phase 2 study of tesetaxel plus a reduced dose of capecitabine in patients with HER2-, HR+ metastatic breast cancer (MBC) who have not previously received a taxane","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University Health Centre","funders":"","keywords":"Capecitabine; Medicine; Taxane; Regimen; Internal medicine; Metastatic breast cancer; Clinical endpoint; Chemotherapy; Oncology; Dosing; Phases of clinical research; Chemotherapy regimen; Breast cancer; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001967403,0.001809333,0.001214227,0.0004480074,0.0005082198,0.001029745,0.001056965,0.001490069,0.005455475],"category_scores_gemma":[0.0009491954,0.0005297761,0.001067866,0.000442221,0.0009955387,0.001105292,0.0003850552,0.003384193,0.0009917255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019758,"about_ca_system_score_gemma":0.001886791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001786204,"about_ca_topic_score_gemma":0.00460954,"domain_scores_codex":[0.999662,0.0001607767,0.00001462678,0.00006306641,0.00003269802,0.00006685291],"domain_scores_gemma":[0.9991952,0.0001403447,0.0001350082,0.00004753335,0.00005648516,0.0004255195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7126659,0.1120038,0.01308632,0.001005025,0.001625115,0.0005191178,0.0005057231,0.003994895,0.05615339,0.000554517,0.01264045,0.08524584],"study_design_scores_gemma":[0.5584521,0.4201837,0.01252297,0.00004614892,0.0003704471,0.0003440451,0.00006927701,0.001607578,0.002999181,0.0001758259,0.003191925,0.00003667476],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901733,0.001538707,0.0003507587,0.0008982883,0.0001399717,0.002662378,0.001602345,0.0001107055,0.002523525],"genre_scores_gemma":[0.9805053,0.001618658,0.002144597,0.00131704,0.0003379487,0.002993321,0.005225582,0.00005780072,0.005799732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005455475,"threshold_uncertainty_score":0.01825035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1067475216173787,"score_gpt":0.4428524557434013,"score_spread":0.3361049341260227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}