{"id":"W3010526315","doi":"10.1503/cmaj.191097","title":"Drug interactions with cannabinoids","year":2020,"lang":"en","type":"article","venue":"Canadian Medical Association Journal","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Research Institute for Aging; University of Toronto; University of Waterloo; McMaster University; Grand River Hospital","funders":"","keywords":"Cannabidiol; Ketoconazole; CYP3A4; Cytochrome P450; Pharmacology; Cannabinol; Tetrahydrocannabinol; Pharmacokinetics; Cannabinoid; CYP2C9; Drug; Chemistry; Medicine; Cannabis; Enzyme; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005618447,0.0001109583,0.0002239559,0.000149084,0.0002515683,0.00009897515,0.0001413844,0.0001043506,0.0111656],"category_scores_gemma":[0.001206025,0.00008577445,0.0001040808,0.0004211557,0.00004860159,0.0001129968,0.00001401084,0.001624736,0.0002598674],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001083203,"about_ca_system_score_gemma":0.00787666,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004174159,"about_ca_topic_score_gemma":0.04277387,"domain_scores_codex":[0.9973418,0.00008489416,0.0002818846,0.0001647812,0.00162372,0.0005029422],"domain_scores_gemma":[0.9943096,0.00001667912,0.00009677555,0.0000848991,0.0006854788,0.004806587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004296094,0.00002139559,0.03817699,0.00001313014,0.00009700995,0.001088842,0.0004856857,0.00000270202,0.00003763799,0.00008112685,0.9477301,0.01222245],"study_design_scores_gemma":[0.001145238,0.0001319642,0.02494804,0.00005032191,0.00003345702,0.001117933,0.0007899769,0.0003028521,0.00006121877,0.000009356824,0.9713061,0.0001035508],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1567459,0.0001216226,0.00007205018,0.8271966,0.0002931667,0.0001521173,0.00001748528,0.00002886891,0.01537224],"genre_scores_gemma":[0.8822175,0.00006819925,0.0001199858,0.08642428,0.004154892,0.0000188764,0.00001772887,0.00003867736,0.0269399],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7407723,"threshold_uncertainty_score":0.9977478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009692414328454468,"score_gpt":0.265221047835777,"score_spread":0.2555286335073226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}