{"id":"W3010535785","doi":"10.1101/2020.03.04.975706","title":"Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact; McMaster University Medical Centre","funders":"Food Allergy Canada","keywords":"Immunology; Immunoglobulin E; Anaphylaxis; Allergy; Immune system; Peanut allergy; Mechanism (biology); Biology; Antigen; Transcriptome; Medicine; Antibody; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000233557,0.0002400038,0.0002513224,0.0002604023,0.0001715794,0.0005189098,0.0001572642,0.0003702362,0.005023337],"category_scores_gemma":[0.0002181301,0.0001061927,0.0002098679,0.0001374457,0.0002675912,0.0002913687,0.0003157291,0.0007421956,0.001790353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273052,"about_ca_system_score_gemma":0.0001775464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001477469,"about_ca_topic_score_gemma":0.000218604,"domain_scores_codex":[0.9999093,0.00001255237,0.000005070407,0.0000203196,0.00003220482,0.0000205582],"domain_scores_gemma":[0.9999028,0.00002033212,0.00001942877,0.00002062763,0.00001620561,0.00002054607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001289097,0.00001739518,0.000265122,0.00007329365,0.000006673339,0.00008847886,0.00001921515,0.000124293,0.9905508,0.0008153764,0.00155934,0.006351036],"study_design_scores_gemma":[0.0000326325,0.0001487942,0.005046579,0.00002133102,0.00001843279,0.0003485792,0.00007866693,0.00195948,0.9612617,0.00214621,0.02892525,0.00001230501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902963,0.01181348,0.04692434,0.005654527,0.003216163,0.00009397937,0.003790008,0.002649574,0.02289495],"genre_scores_gemma":[0.9568635,0.003727362,0.01004045,0.000993426,0.0004660225,0.00007679636,0.001618804,0.0003500404,0.02586358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005023337,"threshold_uncertainty_score":0.0168047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01897315307880701,"score_gpt":0.2218922054765652,"score_spread":0.2029190523977582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}