{"id":"W3010538789","doi":"10.3389/fimmu.2020.00369","title":"Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer","year":2020,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":561,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"Northern Ontario Academic Medicine Association","keywords":"Microsatellite instability; Nivolumab; Pembrolizumab; DNA mismatch repair; Immune checkpoint; Immunotherapy; Immune system; Colorectal cancer; Blockade; Medicine; Cancer research; Tumor-infiltrating lymphocytes; Immunology; Cancer; Biology; Internal medicine; Genetics; Microsatellite; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004198416,0.0001510412,0.0004438414,0.0004623241,0.00009263616,0.0005369316,0.0001472486,0.0003085801,0.0006985355],"category_scores_gemma":[0.001024875,0.00006873823,0.0002976947,0.0005781703,0.0001922528,0.0003882894,0.0002440094,0.0006336476,0.0001472266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000284528,"about_ca_system_score_gemma":0.0002346973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004705052,"about_ca_topic_score_gemma":0.0007389034,"domain_scores_codex":[0.9998218,0.0000537924,0.00002674543,0.00003401339,0.00004098426,0.00002268948],"domain_scores_gemma":[0.9996591,0.0001787124,0.00009077552,0.000005758518,0.00004260491,0.00002302386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001010373,0.0001312437,0.07573954,0.01272071,0.0009991543,0.0009997461,0.0004528197,0.001672501,0.01529243,0.003984606,0.01253719,0.8744597],"study_design_scores_gemma":[0.0000920602,0.002013245,0.5065551,0.006957179,0.002098619,0.01339459,0.001030293,0.001446782,0.00646105,0.01035938,0.4494611,0.0001305431],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02985491,0.9669687,0.0004616934,0.001137459,0.0001537843,0.000009095005,0.000111566,0.00001366119,0.001289112],"genre_scores_gemma":[0.136793,0.8584857,0.001060126,0.001291007,0.0007332711,0.00003999886,0.0003500091,0.000009215551,0.001237617],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0006985355,"threshold_uncertainty_score":0.00233686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03181026570287831,"score_gpt":0.3119574145819649,"score_spread":0.2801471488790866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}