{"id":"W3010553242","doi":"10.1158/1538-7445.sabcs19-ot3-17-01","title":"Abstract OT3-17-01: OPTIMA: A prospective randomized trial to validate the clinical utility and cost-effectiveness of gene expression test-directed chemotherapy decisions in mostly node-positive early breast cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Institute of Health Economics; University of Alberta","funders":"","keywords":"Medicine; Breast cancer; Oncology; Internal medicine; Population; Randomized controlled trial; Chemotherapy; Cancer; Lymph node; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006287617,0.001997881,0.00352221,0.0004350943,0.0003990167,0.001628471,0.00109832,0.002650966,0.01918006],"category_scores_gemma":[0.01023629,0.0006880292,0.004379872,0.0005179437,0.00199915,0.001583815,0.0008582401,0.004369237,0.001716933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001513406,"about_ca_system_score_gemma":0.001581764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092252,"about_ca_topic_score_gemma":0.0008942841,"domain_scores_codex":[0.9958965,0.00303167,0.000199965,0.0004730487,0.0001632098,0.0002356613],"domain_scores_gemma":[0.9920352,0.0041702,0.001969852,0.0006393888,0.0002805079,0.0009048415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9925874,0.001251728,0.0003017922,0.0003713174,0.0005758012,0.00000959058,0.00001192228,0.0003099979,0.0002498536,0.0001313564,0.0003801624,0.003819057],"study_design_scores_gemma":[0.9512269,0.04463749,0.001033272,0.0001061608,0.0008668178,0.00001754537,0.00001261991,0.001078688,0.000162417,0.0004526189,0.000388268,0.00001725498],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601733,0.008185421,0.00338902,0.002569293,0.001516327,0.01429543,0.004338195,0.0003022951,0.005230783],"genre_scores_gemma":[0.9735591,0.001352785,0.00411347,0.001114874,0.0005836731,0.01438681,0.001904087,0.00005267732,0.002932558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01918006,"threshold_uncertainty_score":0.06416368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08665620771487301,"score_gpt":0.4397613743258074,"score_spread":0.3531051666109344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}