{"id":"W3010553652","doi":"10.1101/2020.03.08.979013","title":"Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem Cells","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; Krembil Foundation","keywords":"Organoid; Induced pluripotent stem cell; Neuroscience; Cell type; Biology; Human brain; Stem cell; Cell biology; Human Induced Pluripotent Stem Cells; Cell; Computational biology; Gene; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001348338,0.000529114,0.0004477706,0.0006130929,0.000319308,0.001014872,0.0004699351,0.0004669446,0.001854622],"category_scores_gemma":[0.0009079808,0.000384339,0.0004756208,0.0004469434,0.0004335094,0.000392385,0.001086932,0.00112761,0.001488713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003458473,"about_ca_system_score_gemma":0.000540008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006403645,"about_ca_topic_score_gemma":0.0007712705,"domain_scores_codex":[0.9995373,0.00006654208,0.00008458831,0.0001230451,0.0001383999,0.00005004566],"domain_scores_gemma":[0.9993138,0.0001695858,0.0001275569,0.0001740007,0.0001248148,0.00009010739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006922211,0.0000165269,0.0002977778,0.00009658456,0.00001521944,0.0001902314,0.00008018122,0.001221632,0.9920124,0.0008531027,0.0005481777,0.004598812],"study_design_scores_gemma":[0.00001762677,0.00009324843,0.0008020221,0.00002530479,0.00002731957,0.0002223271,0.00003453181,0.001931228,0.9814842,0.0002913949,0.01505789,0.00001291335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4133078,0.00425209,0.5484994,0.0006483931,0.0004543305,0.001945689,0.01467522,0.003443278,0.01277385],"genre_scores_gemma":[0.7832596,0.00332801,0.1906031,0.0002213763,0.00005509641,0.001052023,0.0127369,0.0008012431,0.007942571],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001854622,"threshold_uncertainty_score":0.007130742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02469391198795484,"score_gpt":0.2246284483903943,"score_spread":0.1999345364024394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}