{"id":"W3010631477","doi":"10.1039/c9mo00168a","title":"Mass spectrometric analysis of core fucosylation and sequence variation in a human–camelid monoclonal antibody","year":2020,"lang":"en","type":"article","venue":"Molecular Omics","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Fucosylation; Monoclonal antibody; Fucose; Chemistry; Glycan; Molecular biology; Antibody; Biochemistry; Biology; Immunology; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724998,0.0001005655,0.0001869808,0.000352296,0.00002890611,0.00002006937,0.0001123027,0.0001070325,0.00002486514],"category_scores_gemma":[0.0001609862,0.0001119234,0.00007658129,0.001298602,0.00004006967,0.000005637767,0.00006215765,0.00009473648,0.000001623841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002065906,"about_ca_system_score_gemma":0.00004366319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005886433,"about_ca_topic_score_gemma":0.00001598992,"domain_scores_codex":[0.9990566,0.00005555024,0.000240373,0.0003062207,0.0001941894,0.0001471157],"domain_scores_gemma":[0.999551,0.000008319297,0.00009634782,0.00018,0.00009104752,0.00007331198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005349433,0.0000224568,0.01856549,0.00001683196,0.0001203888,0.00000920062,0.00006294849,0.00313112,0.976964,0.0007640823,0.000003423828,0.0002865535],"study_design_scores_gemma":[0.001102646,0.0004553359,0.1597845,0.000007522579,0.0001577592,0.0000032522,0.00004046818,0.1219327,0.7154566,0.0005297008,0.0002461198,0.0002833768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9534306,0.000196225,0.04578625,0.0001686228,0.000009389908,0.0001848588,0.00003040514,0.00000533357,0.0001883425],"genre_scores_gemma":[0.9970312,0.0000935231,0.002220604,0.0001298589,0.00001976827,0.000006472188,0.0004734158,0.00001131355,0.000013832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2615074,"threshold_uncertainty_score":0.4564105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02958217308922314,"score_gpt":0.3211590984025713,"score_spread":0.2915769253133482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}