{"id":"W3010636467","doi":"10.3390/biom10030369","title":"Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioconjugation; Linker; Azide; Moiety; Peptide; Alkyne; Chemistry; Combinatorial chemistry; Biomolecule; Labelling; Click chemistry; Small molecule; Peptide synthesis; Fluorescence; Conjugate; Chemical biology; Stereochemistry; Biochemistry; Organic chemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003071244,0.0001207066,0.0000977325,0.000008941779,0.0001133896,0.00004117186,0.0001479424,0.00008238378,0.0003280413],"category_scores_gemma":[0.00003310653,0.0001282786,0.00009565135,0.0001071866,0.0000487881,0.00002122266,0.00003230082,0.00005867601,0.0001308764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002415784,"about_ca_system_score_gemma":0.00001790815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003138175,"about_ca_topic_score_gemma":8.055677e-7,"domain_scores_codex":[0.9992397,0.000003885797,0.0001905307,0.0003081704,0.00009209525,0.000165623],"domain_scores_gemma":[0.9995694,0.00002807498,0.00007378354,0.0001941899,0.00004489364,0.00008964172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000230213,0.00003848701,0.00002042121,0.0001319048,0.00001220044,0.000001315919,0.00008335223,0.000004299309,0.9941919,0.001181958,0.001722282,0.0025888],"study_design_scores_gemma":[0.0002595358,0.000008756797,0.000001685842,0.00001847624,0.000009677169,9.494353e-7,0.00005501788,0.0003727308,0.7980973,0.0001433752,0.2009084,0.0001241969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829707,0.0008229652,0.01005752,0.003373123,0.00001434846,0.0003289417,0.0002212374,0.0002186494,0.001992554],"genre_scores_gemma":[0.9948668,0.000028979,0.003382742,0.0001967418,0.0003210888,0.0003227382,0.0003798615,0.0000258839,0.0004751784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1991861,"threshold_uncertainty_score":0.5231051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04206241308386578,"score_gpt":0.2563105721907251,"score_spread":0.2142481591068593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}