{"id":"W3010636467","doi":"10.3390/biom10030369","title":"Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation","year":2020,"lang":"en","type":"article","venue":"Biomolecules","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioconjugation; Linker; Azide; Moiety; Peptide; Alkyne; Chemistry; Combinatorial chemistry; Biomolecule; Labelling; Click chemistry; Small molecule; Peptide synthesis; Fluorescence; Conjugate; Chemical biology; Stereochemistry; Biochemistry; Organic chemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005795665,0.000715093,0.0003219429,0.0003413269,0.000161722,0.0002802922,0.000414187,0.0006796268,0.0009256962],"category_scores_gemma":[0.0003195876,0.0002336577,0.0002902527,0.0002683037,0.0003816074,0.0004156875,0.0003087881,0.000734145,0.0006317848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005838798,"about_ca_system_score_gemma":0.0002818032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002770532,"about_ca_topic_score_gemma":0.0005049439,"domain_scores_codex":[0.9996752,0.00007495978,0.00002118427,0.00008288576,0.0001001138,0.00004570255],"domain_scores_gemma":[0.9998457,0.00004433979,0.00004136606,0.00002501221,0.00002294864,0.00002047202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002089332,0.00001423626,0.00004932032,0.00005987164,0.000003694617,0.00004353001,0.00001568936,0.00008174123,0.9969368,0.0005248837,0.00005540063,0.002193968],"study_design_scores_gemma":[0.000002665686,0.00003556794,0.000130571,0.000002438538,0.000004852434,0.0001001679,0.00000194193,0.0003353745,0.996159,0.00002429987,0.00320011,0.000003016608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5992639,0.01152534,0.3802461,0.0004971925,0.000203157,0.0003435125,0.0003310309,0.0007287478,0.006861067],"genre_scores_gemma":[0.8684015,0.006788,0.1158036,0.000283489,0.00007356193,0.0002320757,0.0006439826,0.00008301831,0.007690814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009256962,"threshold_uncertainty_score":0.0042364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04206241308386578,"score_gpt":0.2563105721907251,"score_spread":0.2142481591068593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}