{"id":"W3010658187","doi":"10.1016/s0735-1097(20)32844-8","title":"EPIGENETIC READER INHIBITOR APABETALONE (RVX-208) COUNTERS PROINFLAMMATORY HYPERACTIVATION OF CD14+ MONOCYTES FROM PATIENTS WITH TYPE 2 DIABETES AND CARDIOVASCULAR DISEASE","year":2020,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Bromodomain; Epigenetics; Medicine; CD14; BET inhibitor; Monocyte; Disease; Proinflammatory cytokine; Type 2 diabetes; Diabetes mellitus; Immunology; Immune system; Bioinformatics; Cancer research; Inflammation; Internal medicine; Endocrinology; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152706,0.0002342432,0.000376422,0.0001425188,0.0001696896,0.000291337,0.0001471388,0.0001916965,0.00224242],"category_scores_gemma":[0.0002244542,0.000126339,0.0001987762,0.00009928614,0.0001353085,0.00008706802,0.0002190791,0.0005964393,0.0003313832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001122289,"about_ca_system_score_gemma":0.0003104317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004180195,"about_ca_topic_score_gemma":0.000941931,"domain_scores_codex":[0.9998739,0.00003266162,0.00001067817,0.00002022332,0.00002086623,0.0000416119],"domain_scores_gemma":[0.999902,0.00001337296,0.00001918775,0.000009467489,0.000009676617,0.00004626562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0137969,0.0007132583,0.01002259,0.0001244579,0.0000702559,0.0002154185,0.00004612176,0.00009946125,0.9475367,0.00007311911,0.000531734,0.02677002],"study_design_scores_gemma":[0.002602217,0.02180853,0.2918331,0.00005363177,0.0004233896,0.001937607,0.000455821,0.002721949,0.6704395,0.0003188547,0.007371044,0.00003432623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976857,0.001076245,0.0003804626,0.000133316,0.00006590809,0.00001496358,0.0001539274,0.00003410421,0.0004553816],"genre_scores_gemma":[0.9978162,0.0004357381,0.000393868,0.00008548278,0.00002975307,0.00002420668,0.0002261465,0.000005457825,0.0009832366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00224242,"threshold_uncertainty_score":0.007501602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006905003939732656,"score_gpt":0.1908365602138003,"score_spread":0.1839315562740677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}