{"id":"W3010667353","doi":"10.1172/jci125898","title":"Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Krembil Foundation","funders":"National Institutes of Health; Krembil Foundation; University of Toronto; Foundation Fighting Blindness; Fondation Brain Canada; Research to Prevent Blindness; Cleveland Clinic Foundation; National Eye Institute; Cleveland Clinic","keywords":"Retinal degeneration; Degeneration (medical); Neutralization; Retinal; Retina; Biology; Cell biology; Ophthalmology; Anatomy; Chemistry; Neuroscience; Medicine; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048028,0.0002827454,0.0002130128,0.0002008806,0.0001011916,0.0001661359,0.0001912985,0.0003124778,0.001005237],"category_scores_gemma":[0.00009203408,0.00009884781,0.0001263852,0.00007271025,0.0002183919,0.0001077842,0.0001279882,0.0005316082,0.000174075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717943,"about_ca_system_score_gemma":0.0002020633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004009232,"about_ca_topic_score_gemma":0.0007743853,"domain_scores_codex":[0.9999226,0.0000141465,0.000008455328,0.00001485507,0.00001910862,0.00002080303],"domain_scores_gemma":[0.9999191,0.00001208976,0.00002169301,0.000007582178,0.000006671089,0.00003290613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002366453,0.00009838744,0.00009574922,0.00003061835,0.000004225693,0.00006035235,0.000009765918,0.00003999686,0.9976544,0.00007126378,0.00003370972,0.00166478],"study_design_scores_gemma":[0.00009167724,0.002252649,0.005505925,0.00001281967,0.00001702467,0.0004451816,0.00003424026,0.0007045026,0.9892796,0.00007119813,0.00158053,0.000004821462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969026,0.001077823,0.0006969028,0.0000617882,0.00002524678,0.00002534757,0.0001137639,0.00007061954,0.001025919],"genre_scores_gemma":[0.9965154,0.0006226572,0.0008642258,0.00004496322,0.000006775495,0.00002016158,0.0001657492,0.00001243003,0.001747686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005237,"threshold_uncertainty_score":0.003362834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05706214646538112,"score_gpt":0.3403940300791723,"score_spread":0.2833318836137912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}