{"id":"W3010667353","doi":"10.1172/jci125898","title":"Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Krembil Foundation","funders":"National Institutes of Health; Krembil Foundation; University of Toronto; Foundation Fighting Blindness; Fondation Brain Canada; Research to Prevent Blindness; Cleveland Clinic Foundation; National Eye Institute; Cleveland Clinic","keywords":"Retinal degeneration; Degeneration (medical); Neutralization; Retinal; Retina; Biology; Cell biology; Ophthalmology; Anatomy; Chemistry; Neuroscience; Medicine; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006429469,0.00008757327,0.0001791479,0.00003856535,0.00002236443,0.00001997914,0.0001117717,0.0001537017,0.00002256155],"category_scores_gemma":[0.00108079,0.00008155537,0.00009901453,0.0001673625,0.00006356529,0.00001986624,0.0000225128,0.0001561083,0.000004450334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009163921,"about_ca_system_score_gemma":0.0001805624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002556206,"about_ca_topic_score_gemma":0.000006944524,"domain_scores_codex":[0.9983807,0.0002369743,0.0009581225,0.0001506984,0.0001793949,0.00009413813],"domain_scores_gemma":[0.9991056,0.00002217226,0.0005121178,0.00005687592,0.000149572,0.0001536367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000614338,0.00006733515,0.7364143,0.00001998084,0.00002625765,0.000006445279,0.0001908966,0.0007630643,0.2552224,0.00004887967,0.00446113,0.002165012],"study_design_scores_gemma":[0.003913619,0.001859716,0.6917566,0.0001237059,0.00003711964,0.00002147912,0.000104089,0.002726293,0.2797638,0.0008803454,0.01845854,0.0003547091],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995927,0.000121561,0.001823288,0.001708083,0.0002305582,0.000104682,0.000001076741,0.000003243648,0.00008047732],"genre_scores_gemma":[0.9942762,0.0003213142,0.003234402,0.001487349,0.0005481135,0.000002307957,0.0000834567,0.00001028198,0.00003653132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04465764,"threshold_uncertainty_score":0.3325732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05706214646538112,"score_gpt":0.3403940300791723,"score_spread":0.2833318836137912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}