{"id":"W3010686323","doi":"10.1093/gerona/glaa060","title":"Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice","year":2020,"lang":"en","type":"article","venue":"The Journals of Gerontology Series A","topic":"Pharmaceutical Practices and Patient Outcomes","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Center for Advancing Translational Sciences; National Institute on Aging; National Institutes of Health","keywords":"Polypharmacy; Deprescribing; Medicine; Observational study; Geriatrics; Adverse effect; Anticholinergic; Drug; Beers Criteria; Internal medicine; Pharmacology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003292089,0.0002144336,0.0005459719,0.0000481549,0.0001231451,0.00002461609,0.00011859,0.00005396347,0.00004734557],"category_scores_gemma":[0.0001789235,0.0001210152,0.0000433633,0.0002157186,0.0003395932,0.0003877711,0.00006317382,0.0006881562,0.000002074883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004518652,"about_ca_system_score_gemma":0.00009125601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007326555,"about_ca_topic_score_gemma":0.0002518557,"domain_scores_codex":[0.9984965,0.0004354314,0.0002816854,0.0002223895,0.0002428057,0.0003212443],"domain_scores_gemma":[0.9986153,0.0006713282,0.0002910503,0.0001374339,0.00007031621,0.0002146068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02913272,0.0001711482,0.8206347,0.0004897753,0.0008800489,0.0001393301,0.00720047,0.0001154018,0.1364251,0.00001316381,0.0009224506,0.003875674],"study_design_scores_gemma":[0.02312578,0.007476163,0.9193748,0.00105004,0.002018437,0.001792003,0.00486178,0.00603395,0.03004871,0.0001157168,0.003490068,0.000612607],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711165,0.006931762,0.00009532194,0.02118875,0.00003414791,0.0004623538,0.000004910402,0.00003090398,0.0001352944],"genre_scores_gemma":[0.9980555,0.0003670224,0.00006904638,0.001257339,0.0001636457,0.00001066586,0.000005341277,0.00002390901,0.00004751715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1063764,"threshold_uncertainty_score":0.4934858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05523672640064411,"score_gpt":0.3395506092261691,"score_spread":0.2843138828255251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}