{"id":"W3010729853","doi":"10.1021/acs.inorgchem.0c00168","title":"H<sub>2</sub><i>CHX</i>hox: Rigid Cyclohexane-Reinforced Nonmacrocyclic Chelating Ligand for [<sup>nat/67/68</sup>Ga]Ga<sup>3+</sup>","year":2020,"lang":"en","type":"article","venue":"Inorganic Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Lundbeckfonden","keywords":"Chemistry; Lipophilicity; Biodistribution; Chelation; Cyclohexane; Nuclear magnetic resonance spectroscopy; Ligand (biochemistry); Dissociation (chemistry); Nuclear chemistry; Stereochemistry; Physical chemistry; In vitro; Inorganic chemistry; Organic chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002480887,0.0007989955,0.0009675653,0.00003683214,0.0004496536,0.0001210336,0.0006642478,0.0007016736,0.0007470418],"category_scores_gemma":[0.0008932932,0.0008401255,0.0005053154,0.0007323051,0.0002950082,0.0002054891,0.0002415812,0.001359793,0.0003161457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936795,"about_ca_system_score_gemma":0.0003849732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006757451,"about_ca_topic_score_gemma":1.673344e-7,"domain_scores_codex":[0.9957597,0.0000217972,0.00118845,0.001269681,0.0006375593,0.001122874],"domain_scores_gemma":[0.9967079,0.0004150413,0.0003384476,0.0009683416,0.0002447678,0.00132549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002574214,0.0001360744,0.0003231487,0.00165411,0.0002432836,0.00005279123,0.0007163601,0.0009617077,0.9885793,0.00001841353,0.006122547,0.0009347827],"study_design_scores_gemma":[0.004031158,0.00007286668,0.00003156415,0.0002136905,0.0004752698,0.0003365206,0.0005349724,0.03249887,0.9321221,0.00005968174,0.02883833,0.0007849479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848407,0.0005724816,0.0008019644,0.004884787,0.00004232743,0.001058608,0.0002107039,0.0005803781,0.007008072],"genre_scores_gemma":[0.9914256,0.0001749393,0.0005980036,0.003100436,0.002101437,0.000271449,0.0005868362,0.000181876,0.001559363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05645723,"threshold_uncertainty_score":0.999405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01926211392098712,"score_gpt":0.2692077025649751,"score_spread":0.249945588643988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}