{"id":"W3010755055","doi":"10.1016/j.jaci.2020.02.026","title":"ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation","year":2020,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada); Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Innate lymphoid cell; Immunology; Interleukin 13; Thymic stromal lymphopoietin; Inflammation; Chemokine; Allergic inflammation; Keratinocyte; Atopic dermatitis; Antigen; Interleukin; Biology; Cytokine; Acquired immune system; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004929674,0.0002357831,0.0007173974,0.0001034025,0.0002073053,0.000012773,0.0002445295,0.0006674549,0.0002288541],"category_scores_gemma":[0.001208775,0.0001987303,0.0002242052,0.0001494436,0.0005826101,0.0003302757,0.0001425078,0.0007933672,0.00005666936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003601466,"about_ca_system_score_gemma":0.0001224032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001605866,"about_ca_topic_score_gemma":0.0000479378,"domain_scores_codex":[0.9972038,0.0006417085,0.00147275,0.0003221935,0.00008418021,0.0002753185],"domain_scores_gemma":[0.9975684,0.0003843995,0.001366965,0.0001942239,0.0004308901,0.00005513962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002278907,0.0002396214,0.001166745,0.00002234886,0.001827026,0.000004572216,0.001469728,0.00002587088,0.9791698,0.0002815741,0.005748503,0.007765272],"study_design_scores_gemma":[0.004493627,0.004164818,0.04325547,0.00008536964,0.0001301273,0.000159918,0.001068037,0.00002367882,0.7565712,0.000317049,0.1894076,0.000323119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934808,0.00183545,0.0002415346,0.003007496,0.0009269848,0.0001503495,0.00006122603,0.00002655778,0.000269596],"genre_scores_gemma":[0.9894399,0.009141677,0.0001760952,0.0002554905,0.0003329821,0.000003745546,0.0001268622,0.00001706701,0.000506178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2225986,"threshold_uncertainty_score":0.8103986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244289631115061,"score_gpt":0.2668881504944428,"score_spread":0.2424591873829366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}