{"id":"W3010808413","doi":"10.1080/2162402x.2020.1736792","title":"LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures","year":2020,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Université de Lausanne; Krebsliga Schweiz; Ludwig Institute for Cancer Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Cancer Research Institute","keywords":"Tumor microenvironment; Blockade; Melanoma; Cancer research; Cytotoxic T cell; Immunotherapy; Cancer immunotherapy; CD8; Immune checkpoint; T cell; Cytokine; Immunology; Antibody; Blocking antibody; Medicine; Immune system; Receptor; Biology; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002746668,0.0002617342,0.0006198811,0.0001795719,0.0001535976,0.00002712736,0.000115827,0.0002567066,0.0002494117],"category_scores_gemma":[0.00007871555,0.0002284486,0.0001066558,0.0002834316,0.00041681,0.00009807944,0.00007564952,0.0004527385,0.00003920894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001212021,"about_ca_system_score_gemma":0.0001384987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003721401,"about_ca_topic_score_gemma":0.00005157685,"domain_scores_codex":[0.9982839,0.0002172651,0.000517066,0.0004507953,0.0001407736,0.0003901889],"domain_scores_gemma":[0.9993387,0.00006685549,0.0001868828,0.0002826548,0.00005017973,0.00007476896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004071506,0.000215198,0.006203793,0.0001204312,0.00008843453,0.000557084,0.002129296,4.495938e-7,0.9824837,0.00009009677,0.0006681571,0.003371808],"study_design_scores_gemma":[0.01222071,0.004473684,0.4573191,0.0002403149,0.00009472339,0.0009027499,0.001233203,0.00002855287,0.4664209,0.0001063848,0.05647568,0.0004840169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828061,0.00843701,0.000007911865,0.005512256,0.0001170329,0.000564708,0.00002440307,0.0001368049,0.002393703],"genre_scores_gemma":[0.9967556,0.0006059817,0.0001667971,0.001656095,0.00008016395,0.00004018216,0.00009296897,0.00003415314,0.0005680816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5160629,"threshold_uncertainty_score":0.9315863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643124921395461,"score_gpt":0.293452555546814,"score_spread":0.2770213063328594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}