{"id":"W3010816477","doi":"10.3390/cancers12030654","title":"MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Health and Medical Research Council","keywords":"Senescence; Temozolomide; Cancer research; DNA damage; Phenotype; Biology; Mutant; MAPK/ERK pathway; Mutation; Cell growth; Gene; Kinase; Glioblastoma; DNA; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009847486,0.0004547087,0.0003455324,0.0002553473,0.0001662146,0.0002226332,0.0001324552,0.0001761156,0.0009848835],"category_scores_gemma":[0.00007764125,0.0001106494,0.0002406206,0.0001991776,0.0001276586,0.0001340744,0.0001868836,0.0004884762,0.0003255491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638909,"about_ca_system_score_gemma":0.0002874082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133506,"about_ca_topic_score_gemma":0.002095347,"domain_scores_codex":[0.999907,0.00001387405,0.00001163684,0.00001222944,0.00002157723,0.00003357538],"domain_scores_gemma":[0.999953,0.000006727873,0.000007505392,0.000006422182,0.000008115983,0.00001815926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005028051,0.0001746588,0.0002556668,0.0001124726,0.00002015197,0.0001011073,0.00004136981,0.0001629782,0.9933669,0.0001658817,0.0004459452,0.004650109],"study_design_scores_gemma":[0.00006614524,0.001247155,0.0043319,0.000008807463,0.00002292995,0.0002451351,0.00002975301,0.001275517,0.9880675,0.00008251219,0.004616932,0.000005729978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910487,0.002998475,0.001405338,0.0001751799,0.0001026758,0.00004887916,0.000685178,0.0002011985,0.003334305],"genre_scores_gemma":[0.9943709,0.001446473,0.0008930843,0.00008816485,0.00001964607,0.00006194004,0.0008881293,0.00002198235,0.002209837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133506,"threshold_uncertainty_score":0.003294766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033105486048944,"score_gpt":0.2580251172236984,"score_spread":0.237694062363209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}