{"id":"W3010847380","doi":"10.1016/j.msard.2019.11.078","title":"Efficacy and Safety of the Bruton's Tyrosine Kinase Inhibitor Evobrutinib in Patients with Relapsing Multiple Sclerosis Over 48 Weeks: A Randomized, Placebo-Controlled, Phase 2 Study","year":2020,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"NeuroRx Research (Canada); University of Toronto; Montreal Neurological Institute and Hospital","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Gastroenterology; Internal medicine; Randomized controlled trial; Confidence interval; Adverse effect; Dimethyl fumarate; Multiple sclerosis; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001757659,0.001931918,0.003755651,0.0005343902,0.0005787152,0.001126305,0.0008411782,0.002196994,0.004119345],"category_scores_gemma":[0.001473258,0.0009219056,0.001863886,0.0004448875,0.001328375,0.001524202,0.0003797578,0.003162595,0.0006945623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007366872,"about_ca_system_score_gemma":0.0007341257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007054923,"about_ca_topic_score_gemma":0.001441143,"domain_scores_codex":[0.9992655,0.0003372527,0.00004338076,0.0001438497,0.00006461408,0.0001455193],"domain_scores_gemma":[0.9990875,0.0002334625,0.0002181369,0.00007147308,0.00006376437,0.0003257544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9677913,0.008340363,0.001071389,0.0003866547,0.0009010109,0.00004881214,0.00005381593,0.000314257,0.00443943,0.00005085874,0.0004040185,0.01619801],"study_design_scores_gemma":[0.8939353,0.09938384,0.004569621,0.00002364857,0.00054121,0.00004621,0.00002480134,0.0003292781,0.0005632631,0.0001004549,0.0004598191,0.00002241044],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926636,0.004216868,0.000274263,0.0002870868,0.0002128411,0.0008200478,0.0004332493,0.00006553976,0.0010264],"genre_scores_gemma":[0.993301,0.001849065,0.0005805709,0.0006523732,0.0003753153,0.001145345,0.0006444909,0.00001974619,0.001431975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004119345,"threshold_uncertainty_score":0.01378053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705043165020081,"score_gpt":0.2431664878634373,"score_spread":0.2261160562132365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}