{"id":"W3010867200","doi":"10.1053/j.gastro.2020.03.017","title":"MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Horizon 2020; Medical Research Council; Vontobel-Stiftung; Deutsche Forschungsgemeinschaft; European Research Council; National Science Foundation; Cancer Research UK; Deutsche Krebshilfe; Wilhelm Sander-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Homeostasis; Carcinogenesis; MCL1; Cancer research; Medicine; Biology; Internal medicine; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001248951,0.00008870909,0.0003257864,0.00007379388,0.00001704101,0.000001118688,0.00009104121,0.00008204269,0.00002888073],"category_scores_gemma":[0.0000770388,0.00008632091,0.00006976371,0.00006672107,0.000156819,0.00004921129,0.00005488935,0.0000563604,0.000001790492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001156972,"about_ca_system_score_gemma":0.00001455668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003800781,"about_ca_topic_score_gemma":0.00002515428,"domain_scores_codex":[0.9991225,0.0001049658,0.0003713683,0.0001906483,0.00001522765,0.0001952729],"domain_scores_gemma":[0.9995792,0.00004641716,0.0002106599,0.00008388691,0.00006730143,0.00001252645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002106677,0.00006815896,0.1054532,0.0001145787,0.00007227924,3.897144e-7,0.0005542539,0.00000561259,0.8840022,0.0001100176,0.0004473307,0.007065295],"study_design_scores_gemma":[0.004979003,0.003494834,0.488862,0.00009832787,0.00008183867,0.00004839811,0.0003212517,0.0001385629,0.5010704,0.0003361336,0.0004854883,0.00008380659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938994,0.001228965,0.003402757,0.001115459,0.00006610666,0.0002193674,0.00005198671,0.000006127716,0.000009802069],"genre_scores_gemma":[0.998971,0.00009072689,0.0006546357,0.0001886802,0.000007249952,0.00001944226,0.00004017982,0.000007014169,0.00002104942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3834088,"threshold_uncertainty_score":0.3520065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688203568267878,"score_gpt":0.2518768746488679,"score_spread":0.2249948389661892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}