{"id":"W3010867200","doi":"10.1053/j.gastro.2020.03.017","title":"MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice","year":2020,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Horizon 2020; Medical Research Council; Vontobel-Stiftung; Deutsche Forschungsgemeinschaft; European Research Council; National Science Foundation; Cancer Research UK; Deutsche Krebshilfe; Wilhelm Sander-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Homeostasis; Carcinogenesis; MCL1; Cancer research; Medicine; Biology; Internal medicine; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000368764,0.0006669536,0.0004870057,0.001987011,0.0005414498,0.001018875,0.0007763552,0.001391092,0.00327163],"category_scores_gemma":[0.0003731268,0.0006421446,0.0005155113,0.0003395213,0.0009787701,0.0005763791,0.0006288826,0.00230159,0.0009538393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008946288,"about_ca_system_score_gemma":0.0004864119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009824702,"about_ca_topic_score_gemma":0.001372374,"domain_scores_codex":[0.9992709,0.00009549267,0.00005675441,0.0001694023,0.0001644288,0.0002431399],"domain_scores_gemma":[0.9985914,0.0001012385,0.000636822,0.000123438,0.00008108902,0.0004659524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007622151,0.00007825377,0.0005951184,0.00004746947,0.00001335102,0.0001713337,0.00002136601,0.0001162142,0.9963698,0.0004279845,0.0001481865,0.001248782],"study_design_scores_gemma":[0.0001446994,0.0005413506,0.01201886,0.00003712381,0.00006341183,0.001252011,0.0001301254,0.002280278,0.9782158,0.0004070289,0.004886003,0.00002332074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852755,0.003504688,0.005429485,0.001053234,0.0001081666,0.00004137621,0.001418872,0.0007338614,0.002434798],"genre_scores_gemma":[0.9919852,0.0005359379,0.002339427,0.0001965386,0.00003001281,0.00004599009,0.000723729,0.0001155824,0.004027646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00327163,"threshold_uncertainty_score":0.01094472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688203568267878,"score_gpt":0.2518768746488679,"score_spread":0.2249948389661892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}