{"id":"W3010901165","doi":"10.1038/s41598-020-61936-w","title":"Recombinant expression, characterization, and quantification in human cancer cell lines of the Anaplastic Large-Cell Lymphoma-characteristic NPM-ALK fusion protein","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; University of Alberta; University of Houston; Ladies Leukemia League; Cancer Prevention and Research Institute of Texas","keywords":"Anaplastic lymphoma kinase; Fusion protein; Anaplastic large-cell lymphoma; Fusion gene; Cancer research; Lymphoma; Molecular biology; Biology; Cell fusion; Cell culture; Nucleophosmin; Gene; Recombinant DNA; Medicine; Biochemistry; Pathology; Immunology; Genetics; Lung cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00058139,0.0005144292,0.0004991148,0.000430208,0.0002774174,0.0005832638,0.0004151632,0.0004700253,0.0005422464],"category_scores_gemma":[0.0005745682,0.0002153464,0.0003267297,0.00107285,0.0002678173,0.0002488142,0.0002593305,0.0006605186,0.0009288339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004015065,"about_ca_system_score_gemma":0.0002490814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001282023,"about_ca_topic_score_gemma":0.001084935,"domain_scores_codex":[0.9990689,0.0002234118,0.0001056336,0.000145052,0.0003894703,0.00006757356],"domain_scores_gemma":[0.999666,0.00009479324,0.00004576702,0.00007868715,0.00009345345,0.00002134159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004371433,0.00005601508,0.00027827,0.00006563438,0.000009894539,0.00004809053,0.00005806028,0.0002062776,0.9975327,0.0001307387,0.0000879174,0.001482599],"study_design_scores_gemma":[0.00001056886,0.0001682444,0.00206806,0.00001028186,0.00002487128,0.0003235043,0.00004131895,0.002744025,0.9891139,0.0000508195,0.005435445,0.0000088376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8816069,0.004624872,0.1026492,0.0003254623,0.000116534,0.0005809442,0.005469028,0.000608528,0.004018492],"genre_scores_gemma":[0.8601797,0.005072865,0.1039049,0.0001728269,0.00005633201,0.0008517202,0.02334973,0.0001835587,0.006228464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001282023,"threshold_uncertainty_score":0.003074706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629782278688369,"score_gpt":0.2508898071827614,"score_spread":0.2345919843958778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}