{"id":"W3010925428","doi":"10.1530/rep-19-0436","title":"FANCD2 is required for the repression of germline transposable elements","year":2020,"lang":"en","type":"article","venue":"Reproduction","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; National Institutes of Health; Université Laval","keywords":"FANCD2; Biology; Psychological repression; Cell biology; FANCA; Piwi-interacting RNA; Germ cell; DNA damage; Fanconi anemia; Germline; DNA repair; Genetics; Transposable element; DNA; Gene; Mutant; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000249738,0.00006884875,0.00008347368,0.000007991971,0.00005266244,0.000004475476,0.0001018078,0.00005633978,0.00002239956],"category_scores_gemma":[0.0001642018,0.00005268401,0.00008326166,0.00006591884,0.00002202791,0.000003917901,0.00002721023,0.00003040832,0.000002609145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004254542,"about_ca_system_score_gemma":0.00001804074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003200764,"about_ca_topic_score_gemma":6.423354e-7,"domain_scores_codex":[0.9991747,0.0000209214,0.0001970021,0.0004138568,0.00009502655,0.00009845861],"domain_scores_gemma":[0.9993014,0.000004597184,0.0001036171,0.0004791887,0.00008542494,0.00002578365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002368945,0.00002374234,0.0001333681,0.00004024083,0.00003570956,9.729177e-8,0.0001099089,0.00009890182,0.9858526,0.00002903963,0.005004114,0.008435376],"study_design_scores_gemma":[0.0002968113,0.0002440994,0.00006255025,0.000006481576,0.00002773388,0.000002054142,0.00004411139,0.0007569254,0.9096584,0.0001014292,0.08874483,0.00005459778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627499,0.001576226,0.02640131,0.007422101,0.0005311602,0.001005238,0.00004506694,0.00004100926,0.0002279951],"genre_scores_gemma":[0.9947832,0.0001948559,0.003068977,0.0002711462,0.0006279461,0.00004506093,0.00006669353,0.00001729292,0.0009248875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08374071,"threshold_uncertainty_score":0.2148392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02697628429832647,"score_gpt":0.2781788256961228,"score_spread":0.2512025413977963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}