{"id":"W3010925428","doi":"10.1530/rep-19-0436","title":"FANCD2 is required for the repression of germline transposable elements","year":2020,"lang":"en","type":"article","venue":"Reproduction","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; National Institutes of Health; Université Laval","keywords":"FANCD2; Biology; Psychological repression; Cell biology; FANCA; Piwi-interacting RNA; Germ cell; DNA damage; Fanconi anemia; Germline; DNA repair; Genetics; Transposable element; DNA; Gene; Mutant; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347588,0.0006346421,0.0002477239,0.0005237512,0.0003808721,0.000410723,0.0004520122,0.000493139,0.003799865],"category_scores_gemma":[0.0002904611,0.0002218961,0.0002761229,0.0002405491,0.0003644676,0.0001888518,0.0004828143,0.0006119816,0.001443715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004934413,"about_ca_system_score_gemma":0.000467953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002029069,"about_ca_topic_score_gemma":0.002637814,"domain_scores_codex":[0.9997997,0.00002147295,0.00001623741,0.00006308802,0.00006176202,0.00003780499],"domain_scores_gemma":[0.9997486,0.00003561301,0.00005533032,0.00002132334,0.00002951012,0.0001095391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001182544,0.00002917203,0.0009887737,0.00004551646,0.00001040046,0.0006219178,0.00001911106,0.0001060201,0.9946461,0.0004280328,0.0005719765,0.002414849],"study_design_scores_gemma":[0.00006780024,0.00006846507,0.03130769,0.00002442776,0.0000266053,0.003661723,0.00005884708,0.002956135,0.9405882,0.0004480184,0.02076078,0.00003127494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696013,0.003644993,0.01183351,0.0005337472,0.0002941031,0.00004347234,0.004242166,0.0009961416,0.008810773],"genre_scores_gemma":[0.9896271,0.0003329372,0.001377716,0.00009869239,0.00001523815,0.00001595154,0.002469063,0.0001365262,0.005926879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003799865,"threshold_uncertainty_score":0.01271176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02697628429832647,"score_gpt":0.2781788256961228,"score_spread":0.2512025413977963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}