{"id":"W3010938670","doi":"10.1186/s12014-020-9269-6","title":"Discovery of a putative blood-based protein signature associated with response to ALK tyrosine kinase inhibition","year":2020,"lang":"en","type":"article","venue":"Clinical Proteomics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada); Espace pour la vie; Hôpital du Sacré-Cœur de Montréal; Centre Hospitalier Universitaire de Sherbrooke; Centre Hospitalier de l’Université de Montréal; McGill University; Institut universitaire de cardiologie et de pneumologie de Québec; IGNIS Innovation (Canada); Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Pfizer Canada; Astex Pharmaceuticals; Pfizer","keywords":"Crizotinib; Medicine; Oncology; Internal medicine; Targeted therapy; Tyrosine kinase; Anaplastic lymphoma kinase; Lung cancer; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306751,0.0002420045,0.0003478805,0.0007495364,0.0001627693,0.0004515202,0.0001301313,0.0003211884,0.0006783045],"category_scores_gemma":[0.0005868795,0.00008167635,0.0001909444,0.0006689006,0.0001499642,0.0001491823,0.0001721858,0.000308601,0.0002112614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002138647,"about_ca_system_score_gemma":0.0001637595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005381118,"about_ca_topic_score_gemma":0.0004365428,"domain_scores_codex":[0.9998695,0.00002566993,0.00001468001,0.00003706442,0.00002857323,0.000024553],"domain_scores_gemma":[0.9996996,0.00006040512,0.0001201954,0.00001543463,0.00004759128,0.00005683532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002839403,0.0001998761,0.4990961,0.0001102913,0.0001530653,0.0007760112,0.00008092725,0.0007485016,0.4766215,0.0001066357,0.0004238163,0.01884392],"study_design_scores_gemma":[0.00004224907,0.0008911336,0.9200156,0.00001052636,0.0001314135,0.00238388,0.0001265404,0.007547087,0.06786618,0.0001886682,0.0007833947,0.00001331861],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998398,0.0003403107,0.0006400553,0.00004016678,0.000004780943,0.000009590804,0.0003464841,0.00001631354,0.000204365],"genre_scores_gemma":[0.9983192,0.00008142341,0.0009684773,0.00003325409,0.000008473815,0.00001048232,0.0003961027,0.00000287918,0.0001797577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007495364,"threshold_uncertainty_score":0.002269149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186463685941213,"score_gpt":0.3505426487374659,"score_spread":0.3186780118780538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}