{"id":"W3010977977","doi":"10.1007/s12035-020-01900-x","title":"Muscarinic Toxin 7 Signals Via Ca2+/Calmodulin-Dependent Protein Kinase Kinase β to Augment Mitochondrial Function and Prevent Neurodegeneration","year":2020,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"National Institute of Neurological Disorders and Stroke; Institute of Neurosciences, Mental Health and Addiction; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Neurodegeneration; AMPK; Muscarinic acetylcholine receptor; Protein kinase A; Endocrinology; Biology; Neuroprotection; Internal medicine; Chemistry; Pharmacology; Cell biology; Kinase; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001198618,0.000342691,0.0003221152,0.00006092026,0.00008405172,0.00004263571,0.0002158928,0.0002342409,0.0000545666],"category_scores_gemma":[0.0001438416,0.0003473209,0.0001345157,0.0001312411,0.00005351601,0.000007450984,0.0002704264,0.0001848848,0.00003553572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001989643,"about_ca_system_score_gemma":0.00007391548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002057886,"about_ca_topic_score_gemma":0.00002219559,"domain_scores_codex":[0.9975675,0.0003974191,0.0003935294,0.001050033,0.0001618908,0.0004296469],"domain_scores_gemma":[0.9990219,0.000009026143,0.0001226733,0.0004236765,0.00008857854,0.0003341238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003680915,0.0001017719,0.00002521709,0.00003139549,0.00005003856,0.00002040686,0.00002658123,0.001670112,0.9869834,0.00006115534,0.0006501944,0.0100116],"study_design_scores_gemma":[0.001116561,0.00205996,0.00025469,0.00000998688,0.0000700017,0.00000864861,0.000005036386,0.0002513751,0.9405766,0.00007451633,0.05520883,0.000363863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694895,0.008181568,0.01973479,0.0006254726,0.0006768362,0.001188688,0.00003972243,0.00003595975,0.00002742554],"genre_scores_gemma":[0.988835,0.0004583284,0.0004137758,0.008940805,0.0007174165,0.0003095109,0.0001773909,0.00005953869,0.0000881875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05455863,"threshold_uncertainty_score":0.9998979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009571065397443339,"score_gpt":0.2206932716595639,"score_spread":0.2111222062621205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}