{"id":"W3010980144","doi":"10.1002/chem.202001140","title":"A Versatile Approach to Dynamic Amide Bond Formation with Imine Nucleophiles","year":2020,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Imine; Nucleophile; Amide; Bond; Chemistry; Peptide bond; Combinatorial chemistry; Organic chemistry; Business","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004247591,0.0008158673,0.000275507,0.0004287848,0.0002874345,0.000414566,0.0007387041,0.0005189587,0.001692367],"category_scores_gemma":[0.0003262099,0.0002896238,0.0002771829,0.0002211117,0.0004865266,0.0005859835,0.0007432073,0.001423552,0.0005793477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002917411,"about_ca_system_score_gemma":0.0002852559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002062161,"about_ca_topic_score_gemma":0.0004062666,"domain_scores_codex":[0.9997836,0.00003552545,0.00001857854,0.00006341581,0.00005550216,0.00004341596],"domain_scores_gemma":[0.9998978,0.00002126401,0.00002575685,0.00001915189,0.00001104152,0.00002484939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007066017,0.00007769166,0.00008326335,0.0002138719,0.00001905838,0.0004149868,0.0001216909,0.0006347068,0.9753495,0.007410619,0.0004190041,0.01518489],"study_design_scores_gemma":[0.00002594948,0.0004452312,0.0001465513,0.0000136162,0.00001626146,0.0004741388,0.00001274908,0.0008337325,0.9761923,0.0004799115,0.02133497,0.0000246089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5868174,0.02240895,0.3325051,0.001635695,0.0008881459,0.0009091683,0.0008840323,0.002025294,0.05192618],"genre_scores_gemma":[0.9225753,0.00899329,0.05749086,0.000423003,0.0001628814,0.0003563334,0.0002846101,0.0001424477,0.00957125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692367,"threshold_uncertainty_score":0.005661488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008988433514185473,"score_gpt":0.1883539853741935,"score_spread":0.179365551860008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}