{"id":"W3010985563","doi":"10.1177/1091581820907324","title":"Monitoring Compound-Related Effects on Coagulability in Rats and Cynomolgus and Rhesus Monkeys by Thrombin Generation Kinetic Measurement","year":2020,"lang":"en","type":"article","venue":"International Journal of Toxicology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Canadian Nuclear Laboratories","funders":"","keywords":"Thrombin; Tissue factor; Coagulation; In vivo; Antithrombin; Chemistry; Clotting time; Pharmacology; Heparin; Anticoagulant; Thrombin time; Thrombin generation; Internal medicine; Medicine; Biochemistry; Platelet; Partial thromboplastin time; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002901408,0.000106965,0.0002877122,0.0001098389,0.00002409915,0.00002499756,0.00007235229,0.00009716076,0.00002117872],"category_scores_gemma":[0.0002526384,0.00009675663,0.00003806705,0.00006112216,0.00003993864,0.00007121263,0.00003251283,0.0002395643,0.000002354641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001578835,"about_ca_system_score_gemma":0.00004648579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007613504,"about_ca_topic_score_gemma":0.000004124672,"domain_scores_codex":[0.9988155,0.0001365854,0.0003774499,0.0001619475,0.0004099352,0.00009856257],"domain_scores_gemma":[0.9992979,0.00008988551,0.0001913436,0.00005077622,0.0002364339,0.0001336193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002647846,0.0002689509,0.01967515,0.00002273964,0.0001884399,0.0001271353,0.0002979062,0.00008150496,0.9705315,0.0003792607,0.0002198952,0.007942698],"study_design_scores_gemma":[0.008352317,0.003530712,0.2329618,0.0002874217,0.0001215355,0.0006204455,0.00007939673,0.004782299,0.7479789,0.0008922724,0.0002243448,0.0001685934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864492,0.0005444068,0.0003055293,0.01161275,0.0008072061,0.0001866558,0.000001412331,0.000008712269,0.00008406623],"genre_scores_gemma":[0.9984912,0.0001338392,0.0003753603,0.0007595661,0.0002190435,0.000003707585,0.000002767039,0.000008948892,0.000005571449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2225527,"threshold_uncertainty_score":0.3945621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05234301407161752,"score_gpt":0.302120304280184,"score_spread":0.2497772902085665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}