{"id":"W3010990547","doi":"10.1080/2162402x.2020.1737385","title":"Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activation","year":2020,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"Memorial Sloan-Kettering Cancer Center","keywords":"Immunohistochemistry; Osteosarcoma; Sarcoma; Undifferentiated Pleomorphic Sarcoma; PD-L1; Medicine; Immune system; Soft tissue sarcoma; Leiomyosarcoma; Cancer research; Liposarcoma; Immune checkpoint; Pathology; Internal medicine; Oncology; Immunotherapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003722124,0.0001729989,0.0002325065,0.0005427648,0.0001820846,0.0003113413,0.0001029313,0.0002181229,0.00153825],"category_scores_gemma":[0.0005173723,0.0001182108,0.0001562686,0.0003370278,0.0002520879,0.0002350217,0.0003147142,0.0002365626,0.0002918513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001244115,"about_ca_system_score_gemma":0.0001112226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000151336,"about_ca_topic_score_gemma":0.0003500875,"domain_scores_codex":[0.9998024,0.00003602485,0.00003079785,0.00005052685,0.00003652731,0.00004389133],"domain_scores_gemma":[0.9995553,0.00008745988,0.0001849232,0.00002887407,0.00004195067,0.0001015212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001954731,0.0001378774,0.963051,0.00005626514,0.00004960406,0.0004443542,0.000146055,0.00009635836,0.02466907,0.00004758054,0.00006670272,0.009280433],"study_design_scores_gemma":[0.00002031611,0.0007273733,0.9940695,0.000007521593,0.0000423746,0.001705748,0.000264684,0.0002369665,0.002453017,0.00008114038,0.000387438,0.000003989198],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992735,0.0002550177,0.0001055626,0.000008442564,0.000001826784,0.000005741308,0.00007114586,0.000002245487,0.0002765955],"genre_scores_gemma":[0.9994336,0.00008408563,0.00007167917,0.000006293494,0.000004897583,0.000009368392,0.0001632577,0.000001043892,0.0002257335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153825,"threshold_uncertainty_score":0.005145967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05069323176655503,"score_gpt":0.3352405762429614,"score_spread":0.2845473444764064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}