{"id":"W3010996890","doi":"10.1158/0008-5472.can-19-3819","title":"Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance <i>EGFR</i> Mutations","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; National Center for Advancing Translational Sciences; Lung Cancer Research Foundation; AstraZeneca","keywords":"Osimertinib; Afatinib; Erlotinib; Lung cancer; Cancer research; Drug resistance; Context (archaeology); Medicine; Mutation; Tyrosine-kinase inhibitor; Biology; Epidermal growth factor receptor; Pharmacology; Cancer; Oncology; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002311029,0.0001532175,0.0001836928,0.0003563693,0.00007992192,0.0002572062,0.000125654,0.0002243231,0.001961855],"category_scores_gemma":[0.0002711257,0.00007432105,0.0001667785,0.0001267761,0.0001651952,0.0001270121,0.0001102929,0.0003489795,0.0002151274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002614086,"about_ca_system_score_gemma":0.00008495528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006709059,"about_ca_topic_score_gemma":0.000507894,"domain_scores_codex":[0.9997961,0.00004380483,0.00002129216,0.00004690192,0.00004740164,0.00004450416],"domain_scores_gemma":[0.9998317,0.00006175852,0.00003767131,0.00001684881,0.00002536417,0.00002661475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002836474,0.00007869772,0.002968281,0.00001342775,0.00001541578,0.00006768683,0.00001884289,0.0002051636,0.9930723,0.0001489203,0.0000794294,0.003048165],"study_design_scores_gemma":[0.00003355605,0.001126177,0.03425024,0.00000501306,0.00005074894,0.001601989,0.00002848392,0.003116262,0.9582435,0.00007736179,0.001459438,0.000007283908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972891,0.0002773258,0.0006730208,0.00002772064,0.000005748899,0.00001339173,0.0002396978,0.00003044691,0.001443634],"genre_scores_gemma":[0.999154,0.0000635434,0.0001923408,0.00001417918,0.00000177007,0.000007046816,0.000169867,0.000006887542,0.0003903479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001961855,"threshold_uncertainty_score":0.006563067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07865828639649587,"score_gpt":0.4131990002546753,"score_spread":0.3345407138581795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}