{"id":"W3010999067","doi":"10.1089/nat.2020.0848","title":"Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells","year":2020,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"","keywords":"Small interfering RNA; RNA interference; Trans-acting siRNA; Sense strand; Gene silencing; Argonaute; Cell biology; Biology; RNA; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007188113,0.000437955,0.0003871933,0.0001969263,0.0002395655,0.0004449931,0.0004097018,0.0003461186,0.0009156774],"category_scores_gemma":[0.0004425246,0.0002697339,0.0003376257,0.0002318316,0.000269656,0.0001808816,0.000163073,0.0004797907,0.0004926489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004767983,"about_ca_system_score_gemma":0.0003373006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591368,"about_ca_topic_score_gemma":0.002551618,"domain_scores_codex":[0.9989849,0.0002666462,0.0001364471,0.0001997532,0.0003446956,0.00006755885],"domain_scores_gemma":[0.999527,0.0002080699,0.0001025399,0.00006157647,0.0000817402,0.00001901375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003200351,0.00001273934,0.00004684871,0.00002057571,0.00000375582,0.00001548921,0.00001521643,0.00006152323,0.999162,0.00003816634,0.00001596591,0.0005757395],"study_design_scores_gemma":[0.00000244313,0.00008643375,0.0002175961,9.351644e-7,0.000004249005,0.0000177264,0.00000346793,0.0002430279,0.9988545,0.000007001016,0.000560419,0.000002062276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476358,0.004264316,0.03914558,0.000147388,0.0001521481,0.0003985238,0.001216002,0.0005572257,0.006482894],"genre_scores_gemma":[0.9342811,0.003320704,0.05273564,0.0002048347,0.00003337227,0.0004071051,0.001737948,0.0001773073,0.00710194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591368,"threshold_uncertainty_score":0.003801525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717371138084542,"score_gpt":0.2425371154601044,"score_spread":0.225363404079259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}