{"id":"W3010999067","doi":"10.1089/nat.2020.0848","title":"Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells","year":2020,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"","keywords":"Small interfering RNA; RNA interference; Trans-acting siRNA; Sense strand; Gene silencing; Argonaute; Cell biology; Biology; RNA; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003000717,0.00009844752,0.0001043169,0.0000230011,0.00001474386,0.000007576919,0.0001347912,0.0001240314,0.00001122123],"category_scores_gemma":[0.000008708956,0.00009655875,0.00005467922,0.0000949073,0.0000369169,0.000002491957,0.00001839069,0.00009876947,0.00001650286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008782315,"about_ca_system_score_gemma":0.00002337158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004243442,"about_ca_topic_score_gemma":0.000002211593,"domain_scores_codex":[0.9994254,0.00003070442,0.0001477902,0.000194783,0.00007859036,0.0001227229],"domain_scores_gemma":[0.9997688,0.000009762565,0.00004808037,0.00009481469,0.00003489292,0.00004363655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001478762,0.00009122451,0.0001451112,0.00002556923,0.00002879662,7.621164e-7,0.0001506724,0.00007733096,0.9959677,0.00004970678,0.0001363315,0.003178856],"study_design_scores_gemma":[0.0004491481,0.0004121633,0.0007503683,0.0000102502,0.00001760333,7.697574e-7,0.00002969367,0.000619269,0.9960812,0.00003820687,0.001495641,0.00009563125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985157,0.0001712222,0.0005398222,0.0002608128,0.00003915802,0.0001315345,0.000006854281,0.000007883358,0.000327006],"genre_scores_gemma":[0.9985873,0.0001173076,0.0001831621,0.0009712427,0.00008306488,0.000006827685,0.00001123516,0.00001446197,0.00002547252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003083225,"threshold_uncertainty_score":0.3937551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717371138084542,"score_gpt":0.2425371154601044,"score_spread":0.225363404079259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}