{"id":"W3011005820","doi":"10.1056/nejmoa1913805","title":"Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":801,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Familial hypercholesterolemia; Medicine; PCSK9; Placebo; Internal medicine; Cholesterol; Endocrinology; Confidence interval; Gastroenterology; Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005583008,0.0001227266,0.0006747021,0.00005031343,0.00004226265,0.000003273897,0.00009781653,0.00004994942,0.00002315018],"category_scores_gemma":[0.0002163615,0.00005539276,0.0002911643,0.0000985507,0.00007402605,0.00002945255,0.000006943448,0.0001470501,0.000001057311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004649954,"about_ca_system_score_gemma":0.0001822061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001571537,"about_ca_topic_score_gemma":0.00001372152,"domain_scores_codex":[0.9987038,0.00005803779,0.0005190388,0.00009811504,0.0004755952,0.0001454082],"domain_scores_gemma":[0.9988872,0.0001912115,0.0002138032,0.0002002966,0.0001746009,0.0003329074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003641632,0.0001152691,0.001748592,0.0001426263,0.0006011697,0.0001052949,0.004942519,0.00004413624,0.005398946,0.00002045381,0.002581324,0.9806581],"study_design_scores_gemma":[0.1603476,0.04221034,0.01065457,0.0003722451,0.001716607,0.001564517,0.0007904225,0.0002122299,0.002648832,0.00009450253,0.7792891,0.00009905001],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318613,0.01580547,0.005931583,0.0449654,0.0005905366,0.0006926338,0.000006974332,0.000008958753,0.0001371463],"genre_scores_gemma":[0.9813934,0.003377,0.0005232801,0.002086887,0.01253669,0.000003658541,0.000004482442,0.00001667977,0.00005794316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.980559,"threshold_uncertainty_score":0.2258851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04857532042122918,"score_gpt":0.3031275938948083,"score_spread":0.2545522734735791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}