{"id":"W3011011396","doi":"10.3390/molecules25061290","title":"Enhancing the Immune Response of a Nicotine Vaccine with Synthetic Small “Non-Natural” Peptides","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Variation Biotechnologies (Canada); NOSM University; Health Sciences North; University of Toronto; Laurentian University; Canada Research Chairs","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Grand Challenges Canada","keywords":"Adjuvant; Nicotine; Immune system; Immunogenicity; Medicine; Vaccination; Peptide vaccine; Pharmacology; Immunology; Conjugate; Peptide; Antibody; Biology; Internal medicine; Epitope; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059308,0.0002948171,0.0001620284,0.0001512939,0.0000654005,0.0002005227,0.0001779707,0.0003198003,0.0005121097],"category_scores_gemma":[0.0002583326,0.0001259875,0.000218515,0.0000833298,0.000146281,0.0002175137,0.0001410503,0.0003741668,0.0001489187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001753011,"about_ca_system_score_gemma":0.0001564372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000940272,"about_ca_topic_score_gemma":0.0001558258,"domain_scores_codex":[0.9998931,0.00002680647,0.000009893844,0.00001765783,0.00003329508,0.00001934945],"domain_scores_gemma":[0.9999082,0.00002612688,0.00002914547,0.000007673856,0.00001746846,0.00001127144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007601191,0.00004599477,0.0001202142,0.00003487477,0.000003949669,0.00002153986,0.000006600436,0.0003054703,0.9982168,0.00003264467,0.000008590549,0.00112731],"study_design_scores_gemma":[0.0000372496,0.002384751,0.001342711,0.000009741764,0.00002285993,0.0002141548,0.00001366778,0.002373322,0.9924101,0.00004688045,0.00113979,0.000004769731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954301,0.0006298764,0.003388717,0.00003571528,0.00001784289,0.00005149793,0.00003698987,0.00001233077,0.0003968841],"genre_scores_gemma":[0.990971,0.0005367697,0.007483483,0.00006239856,0.00001218061,0.00004326804,0.00017333,0.00000880275,0.0007087486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005121097,"threshold_uncertainty_score":0.001713216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007630909969467856,"score_gpt":0.2070228489021576,"score_spread":0.1993919389326898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}