{"id":"W3011011396","doi":"10.3390/molecules25061290","title":"Enhancing the Immune Response of a Nicotine Vaccine with Synthetic Small “Non-Natural” Peptides","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Variation Biotechnologies (Canada); NOSM University; Health Sciences North; University of Toronto; Laurentian University; Canada Research Chairs","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Grand Challenges Canada","keywords":"Adjuvant; Nicotine; Immune system; Immunogenicity; Medicine; Vaccination; Peptide vaccine; Pharmacology; Immunology; Conjugate; Peptide; Antibody; Biology; Internal medicine; Epitope; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004328372,0.0002448971,0.0004051547,0.00007039108,0.0001961528,0.00001700425,0.0004496996,0.0001067847,0.0001738611],"category_scores_gemma":[0.0003714216,0.0001458654,0.000143108,0.0002562163,0.0002220051,0.00004877721,0.0001082702,0.0003433603,0.0001165581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001416335,"about_ca_system_score_gemma":0.0000968512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006979326,"about_ca_topic_score_gemma":0.00001147172,"domain_scores_codex":[0.9983372,0.0005918153,0.000426269,0.0002662595,0.0000461724,0.0003322704],"domain_scores_gemma":[0.998564,0.0006689958,0.0002118609,0.0004492648,0.00008972549,0.00001614259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01472597,0.0000594632,0.00007559895,0.00003047877,0.0002885692,0.000007704802,0.001882721,0.00001662618,0.981225,0.00007895881,0.0001075132,0.001501423],"study_design_scores_gemma":[0.001553539,0.0009236498,0.01015768,0.0001411151,0.00006469819,0.00008614139,0.0008392514,0.00001215391,0.9804291,0.000007861251,0.005593812,0.0001909833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678097,0.02725159,0.000968969,0.003402172,0.0001225927,0.0002912415,0.000008424004,0.00005989951,0.00008535699],"genre_scores_gemma":[0.9976144,0.000167784,0.0002604885,0.0005785531,0.00001388744,0.00002298321,0.00001383315,0.00003543766,0.001292636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02980464,"threshold_uncertainty_score":0.5948219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007630909969467856,"score_gpt":0.2070228489021576,"score_spread":0.1993919389326898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}