{"id":"W3011033328","doi":"10.1101/2020.03.19.20031138","title":"Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Medicinska fakulteten, Umeå Universitet; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Hellenic Health Foundation; Junta de Castilla y León; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; University of Cambridge; ZonMw; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; European Commission; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Generalitat de Catalunya; Food Standards Agency; Kempe Foundation; Conseil Régional des Pays de la Loire; Matthias Lackas-Stiftung; Génome Québec; KWF Kankerbestrijding; Wageningen University and Research; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Institut Gustave-Roussy; Grantová Agentura České Republiky; Johns Hopkins University; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute; Cancer Research Foundation in Northern Sweden; Harvard T.H. Chan School of Public Health; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; University of Pittsburgh; World Cancer Research Fund International; Association Anne de Bretagne Genetique; McGill University; Moffitt Cancer Center; Pelotonia; Wereld Kanker Onderzoek Fonds; Brigham and Women's Hospital; American Cancer Society; University of South Florida; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Medicine; Colorectal cancer; Body mass index; Odds ratio; Internal medicine; Oncology; Confidence interval; Obesity; Cancer; Waist–hip ratio; Waist; Endocrinology; Genetics; Biology; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004224671,0.0003690598,0.0006019436,0.00007024177,0.0001182544,0.00007957486,0.0002929512,0.0002920589,0.00003625147],"category_scores_gemma":[0.0001918042,0.0003456588,0.0001666216,0.0001035711,0.00008045884,0.000003683747,0.0007815021,0.0003764943,0.000003993383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000189955,"about_ca_system_score_gemma":0.0002207721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016561,"about_ca_topic_score_gemma":0.001369416,"domain_scores_codex":[0.9979206,0.0003346346,0.0003651501,0.0008880273,0.0002280446,0.0002635925],"domain_scores_gemma":[0.9989955,0.00001684741,0.0002681401,0.0003873899,0.0001328123,0.0001992585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002953395,0.0004708499,0.5656551,0.0002585743,0.002672593,0.000001619286,0.002041098,0.000693142,0.3936768,0.00006220157,0.01781442,0.01370022],"study_design_scores_gemma":[0.01598973,0.0005481992,0.3870331,0.00007298961,0.003140385,0.00001096585,0.0003283955,0.0006890053,0.07950675,0.0004159535,0.5106325,0.001632055],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625077,0.02646137,0.0006273244,0.0001955052,0.008411461,0.001179157,0.0003323504,0.00003789303,0.0002472364],"genre_scores_gemma":[0.9710616,0.01525112,0.000232626,0.0001657691,0.0123625,0.0003699216,0.0002587028,0.00005812859,0.0002396472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4928181,"threshold_uncertainty_score":0.9998996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129654466785551,"score_gpt":0.2692672196137052,"score_spread":0.2563017729351501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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