{"id":"W3011033328","doi":"10.1101/2020.03.19.20031138","title":"Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Medicinska fakulteten, Umeå Universitet; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Hellenic Health Foundation; Junta de Castilla y León; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; University of Cambridge; ZonMw; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; European Commission; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Generalitat de Catalunya; Food Standards Agency; Kempe Foundation; Conseil Régional des Pays de la Loire; Matthias Lackas-Stiftung; Génome Québec; KWF Kankerbestrijding; Wageningen University and Research; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Institut Gustave-Roussy; Grantová Agentura České Republiky; Johns Hopkins University; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Division of Cancer Prevention, National Cancer Institute; Cancer Research Foundation in Northern Sweden; Harvard T.H. Chan School of Public Health; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; University of Pittsburgh; World Cancer Research Fund International; Association Anne de Bretagne Genetique; McGill University; Moffitt Cancer Center; Pelotonia; Wereld Kanker Onderzoek Fonds; Brigham and Women's Hospital; American Cancer Society; University of South Florida; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Medicine; Colorectal cancer; Body mass index; Odds ratio; Internal medicine; Oncology; Confidence interval; Obesity; Cancer; Waist–hip ratio; Waist; Endocrinology; Genetics; Biology; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01723777,0.001233203,0.00170883,0.0007906653,0.0004676355,0.0008054866,0.0009658898,0.001015843,0.003090186],"category_scores_gemma":[0.03514074,0.0005752257,0.001675508,0.001094472,0.0008353629,0.0005044708,0.0004769914,0.000671842,0.0002587662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898474,"about_ca_system_score_gemma":0.0006894279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002049079,"about_ca_topic_score_gemma":0.00101184,"domain_scores_codex":[0.9783803,0.01693073,0.0007559878,0.002380048,0.001247768,0.0003052387],"domain_scores_gemma":[0.9859475,0.00727906,0.002418668,0.003584752,0.0005056214,0.0002644681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1129121,0.001612559,0.7261984,0.00126073,0.0415939,0.003973171,0.0008617745,0.006556754,0.01371449,0.01352574,0.009190763,0.06859966],"study_design_scores_gemma":[0.06248602,0.0320257,0.5885105,0.0006040607,0.05452293,0.01978195,0.0006400993,0.1664543,0.009459368,0.04312027,0.02178669,0.0006080313],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8872553,0.003693462,0.1017518,0.0009512572,0.0004170561,0.001587997,0.001832595,0.0005192584,0.001991332],"genre_scores_gemma":[0.9808803,0.0003667416,0.01650057,0.0003456924,0.00007587436,0.0007890404,0.0004151938,0.00005361177,0.0005729857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01723777,"threshold_uncertainty_score":0.0911631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129654466785551,"score_gpt":0.2692672196137052,"score_spread":0.2563017729351501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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