{"id":"W3011044624","doi":"10.1158/1535-7163.mct-19-0745","title":"Decitabine Response in Breast Cancer Requires Efficient Drug Processing and Is Not Limited by Multidrug Resistance","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Cancer Centre; Dalhousie University","funders":"Nova Scotia Health Research Foundation; Canadian Institutes of Health Research; Cancer Research Society; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Decitabine; Cancer research; DNA methylation; Triple-negative breast cancer; Cancer; Breast cancer; Demethylating agent; Biology; Azacitidine; Medicine; Oncology; Internal medicine; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002049936,0.0002286551,0.0001919149,0.00004330149,0.00008012378,0.00005557826,0.0001637308,0.000127741,0.00001098983],"category_scores_gemma":[0.00002240238,0.0002299049,0.00005285563,0.0002440539,0.00009599946,0.000005424137,0.00008131232,0.000135455,8.577404e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004907353,"about_ca_system_score_gemma":0.0001341146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005940834,"about_ca_topic_score_gemma":0.00005841186,"domain_scores_codex":[0.9985088,0.0001515668,0.0002821801,0.0005348575,0.000228354,0.000294285],"domain_scores_gemma":[0.9993904,0.00001825242,0.0001208479,0.0002291865,0.0001209545,0.0001203284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001832953,0.00004401466,0.002545557,0.00004804615,0.00004107327,0.000005938126,0.0008722907,0.001081766,0.9842715,0.000002996573,0.0001889913,0.009064819],"study_design_scores_gemma":[0.001286153,0.00006594901,0.008972608,0.00007937384,0.00004507647,8.926534e-7,0.00009304775,0.006092373,0.9494934,0.00001675201,0.03348268,0.0003716987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9332768,0.04771439,0.002186303,0.01631592,0.00004852609,0.0002380051,0.0001786814,0.00001521953,0.00002614438],"genre_scores_gemma":[0.9881451,0.004149341,0.0004478785,0.006935214,0.00006653864,0.00005995935,0.00002517312,0.00005225165,0.0001185045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05486833,"threshold_uncertainty_score":0.937525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684294837552151,"score_gpt":0.2833269111630761,"score_spread":0.2664839627875545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}