{"id":"W3011079219","doi":"10.1016/j.msard.2019.11.051","title":"Efficacy of Satralizumab As Monotherapy in Pre-Specified Subgroups of Sakurastar, a Double-Blind Placebo-Controlled Phase 3 Clinical Study in Patients with Neuromyelitis Optica Spectrum Disorder (NMOSD)","year":2020,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Neuromyelitis optica; Placebo; Internal medicine; Serostatus; Clinical endpoint; Hazard ratio; Gastroenterology; Multiple sclerosis; Confidence interval; Clinical trial; Immunology; Pathology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001267307,0.001329901,0.003030372,0.0004425078,0.0004827427,0.0008078842,0.0008480407,0.001381824,0.003505204],"category_scores_gemma":[0.0008837286,0.0005406853,0.001869566,0.0003061234,0.0008829487,0.000838118,0.0003143256,0.002573718,0.0008052721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005527676,"about_ca_system_score_gemma":0.001064557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008328033,"about_ca_topic_score_gemma":0.001887824,"domain_scores_codex":[0.9995998,0.0001685701,0.00003955324,0.00007858932,0.0000302395,0.00008333493],"domain_scores_gemma":[0.9994186,0.0001309992,0.0001099215,0.00004628724,0.00005223258,0.0002420227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9553202,0.007282637,0.001224096,0.0005243898,0.0008740389,0.00006002033,0.00007935198,0.0002796082,0.01020822,0.00005310306,0.0006265916,0.02346763],"study_design_scores_gemma":[0.783062,0.2057452,0.007711724,0.00003268374,0.0007123222,0.00006975684,0.00005758286,0.00044364,0.001380467,0.00008405851,0.0006763793,0.00002412544],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926086,0.004073037,0.0002805906,0.0003062369,0.0002462194,0.0009139681,0.0004249141,0.0001050186,0.0010414],"genre_scores_gemma":[0.9945557,0.001482175,0.000590197,0.0004858496,0.0002146745,0.0009161641,0.0006689734,0.00001761275,0.001068609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003505204,"threshold_uncertainty_score":0.01172608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02985458499056266,"score_gpt":0.2756057949033446,"score_spread":0.2457512099127819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}