{"id":"W3011150630","doi":"10.1172/jci99027","title":"Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Australian Research Council; South Australian Health and Medical Research Institute; National Health and Medical Research Council; Hospital Research Foundation","keywords":"Lymphangiogenesis; Cell biology; Biology; Lymphatic system; Cadherin; Lymphatic Endothelium; Morphogenesis; Cell polarity; Cancer research; Genetics; Immunology; Gene; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320856,0.0001716413,0.0001290579,0.0003641491,0.0001750559,0.000309918,0.0001830013,0.0002270215,0.0007899921],"category_scores_gemma":[0.0002186447,0.00008428553,0.0000708303,0.0001472125,0.0003775776,0.0002299178,0.0003248364,0.0002092018,0.0001568818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003631553,"about_ca_system_score_gemma":0.0002109346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000762651,"about_ca_topic_score_gemma":0.0009002318,"domain_scores_codex":[0.9998962,0.00002390372,0.000005445314,0.00001092596,0.00002729057,0.00003619429],"domain_scores_gemma":[0.9999253,0.00001210956,0.00001725515,0.000006117688,0.00001651914,0.00002265503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000341935,0.0000322403,0.006797671,0.00005886558,0.000008568384,0.0008763208,0.00006416332,0.0003444028,0.9829556,0.001394303,0.0002477261,0.006878262],"study_design_scores_gemma":[0.0001090913,0.0003450226,0.1136235,0.00002713077,0.00003760511,0.004323075,0.0004134973,0.009726153,0.8552697,0.001459162,0.01464597,0.00002007359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932942,0.001156523,0.002604177,0.0001072646,0.00001686095,0.00001775753,0.00009188255,0.00006508891,0.002646186],"genre_scores_gemma":[0.9974244,0.0003666062,0.0008370798,0.00002507695,0.000005565,0.000008841032,0.00007076155,0.000004687733,0.001256975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007899921,"threshold_uncertainty_score":0.00264281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1171577840787237,"score_gpt":0.3833769492531584,"score_spread":0.2662191651744347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}