{"id":"W3011154449","doi":"10.1126/science.aay6690","title":"The genetic architecture of the human cerebral cortex","year":2020,"lang":"en","type":"review","venue":"Science","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":887,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; University of Calgary; McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Cilag; FP7 Ideas: European Research Council; NIH Clinical Center; U.S. National Library of Medicine; National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Mental Health; National Institute on Aging; National Human Genome Research Institute; Helmholtz Zentrum München; European Regional Development Fund; National Health and Medical Research Council; Biotechnology and Biological Sciences Research Council; European Social Fund; Medical Research Council; Maryland Population Research Center, University of Maryland; Horizon 2020 Framework Programme; University of California, Irvine; University of California, San Diego; Gillings School of Public Health; Directorate-General for Research and Innovation; Genentech; Directorate for Biological Sciences; National Institutes of Health; Max Planck Instituut voor Psycholinguïstiek; Macquarie Group Foundation; Heinz Nixdorf Stiftung; Epilepsy Society; IXICO; Freistaat Sachsen; Damp Stiftung; Servier; National Healthcare Group; Instituto de Investigación Marqués de Valdecilla; Medizinische Universität Graz; National Center for Research Resources; Federalno Ministarstvo Obrazovanja i Nauke; Mutuelle Générale de l'Education Nationale; Universidade Estadual de Campinas; Université de Bordeaux; University of New South Wales; Radboud Universitair Medisch Centrum; Universitair Medisch Centrum Groningen; Universitetet i Bergen; Helse Midt-Norge; Oesterreichische Nationalbank; F. Hoffmann-La Roche; University of Toronto; Stanley Medical Research Institute; Science and Technology Commission of Shanghai Municipality; University College London Hospitals NHS Foundation Trust; Erasmus Medisch Centrum; Radboud Universiteit; Russian Foundation for Basic Research; Vrije Universiteit Amsterdam; Neuraxpharm; Vetenskapsrådet; Norges Teknisk-Naturvitenskapelige Universitet; Universiteit Utrecht; Ministry of Education of the People's Republic of China; ZonMw; NSW Health; National Natural Science Foundation of China; National Medical Research Council; Norges Forskningsråd; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Stockholms Läns Landsting; National Heart, Lung, and Blood Institute; Universiteit Leiden; H. Lundbeck A/S; European Federation of Pharmaceutical Industries and Associations; Institut National de la Santé et de la Recherche Médicale; Australian Schizophrenia Research Bank; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; University of Galway; Science Foundation Ireland; Fundação de Amparo à Pesquisa do Estado de São Paulo; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; European Commission; Scottish Funding Council; Massachusetts General Hospital; University College London; Helse Sør-Øst RHF; Max-Planck-Gesellschaft; King's College London; National Institute of Diabetes and Digestive and Kidney Diseases; Lieber Institute for Brain Development; Alzheimer's Association; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; Fresenius Medical Care North America; QIMR Berghofer Medical Research Institute; Austrian Science Fund; National Institute for Health and Care Research; Pratt Foundation; Trinity College Dublin; University of Bristol; Foundation for the National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; Health Research Board; Northern California Institute for Research and Education; Michael J. Fox Foundation for Parkinson's Research; Sanofi; Eisai; Leids Universitair Medisch Centrum; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Sunovion; Sylvia and Charles Viertel Charitable Foundation; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Centre for Cognitive Ageing and Cognitive Epidemiology; Simons Foundation; School of Medicine, Boston University; Agence Nationale de la Recherche; Wellcome Trust; Fondation de l'Avenir pour la Recherche Médicale Appliquée; National Institute on Drug Abuse; Age UK; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Southern California; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Fondation Leducq; National Science Foundation; BioClinica; Kavli Foundation; Ramsay Health Care; Biogen; Hersenstichting; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; U.S. Department of Health and Human Services; Mayo Clinic; GlaxoSmithKline; Karolinska Institutet; U.S. Department of Veterans Affairs; U.S. Department of Energy; Cardiff University; Howard Hughes Medical Institute; Meso Scale Diagnostics; Fondation pour la Recherche Médicale; South London and Maudsley NHS Foundation Trust; Fondation de France; Brain and Behavior Research Foundation; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Bergens Forskningsstiftelse; Karl-Franzens-Universität Graz; Svenska Forskningsrådet Formas; Center of Excellence for Stress and Mental Health","keywords":"Neuroscience; Cerebral cortex; Biology; Cortex (anatomy); Functional magnetic resonance imaging; Human brain; Genetic architecture; Gene; Genetics; Quantitative trait locus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008566304,0.0004670579,0.0004636529,0.001416298,0.000417713,0.0009399452,0.0005634138,0.0004942036,0.003084349],"category_scores_gemma":[0.002672828,0.000263147,0.0007038762,0.001932414,0.000905913,0.0003120956,0.0006090509,0.0003263257,0.0002374459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004029156,"about_ca_system_score_gemma":0.0004905816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009717906,"about_ca_topic_score_gemma":0.005759851,"domain_scores_codex":[0.9990257,0.0002543296,0.00005692411,0.0004460342,0.0001382911,0.00007879658],"domain_scores_gemma":[0.9991463,0.0003263053,0.0002845529,0.0001011001,0.00009296605,0.00004862832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000619627,0.00004578628,0.8954772,0.0003993595,0.00379292,0.001661173,0.0004530051,0.006401963,0.03196166,0.004213314,0.001474811,0.05349912],"study_design_scores_gemma":[0.00002579644,0.00005500097,0.9893476,0.00006394235,0.000497398,0.001229609,0.0001011674,0.001605143,0.001119068,0.004876545,0.001059876,0.00001877733],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9830993,0.0050143,0.006751862,0.0005191388,0.00002563738,0.00003381725,0.002458517,0.000107798,0.001989583],"genre_scores_gemma":[0.9958605,0.0009070672,0.002196673,0.0000536835,0.00002184146,0.00002664764,0.0006730721,0.00001556153,0.0002450794],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.009717906,"threshold_uncertainty_score":0.01932269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02169387638962951,"score_gpt":0.3196245951313482,"score_spread":0.2979307187417187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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