{"id":"W3011181181","doi":"10.1101/2020.03.12.20034165","title":"Molecular landscape of pelvic organ prolapse provides insights into disease etiology and clues towards putative novel treatments","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Pelvic floor disorders treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Radboud Universitair Medisch Centrum; Jewish General Hospital; Radboud Universiteit","keywords":"Candidate gene; Biology; Exome sequencing; Gene; Single-nucleotide polymorphism; Disease; Exome; Bioinformatics; Medicine; Computational biology; Internal medicine; Genetics; Phenotype; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003996028,0.0003863075,0.0008441692,0.00146267,0.0003507384,0.001021894,0.0004140794,0.0004945516,0.002760165],"category_scores_gemma":[0.0006301263,0.0002346029,0.0007493743,0.001179576,0.000409593,0.0007116962,0.0004942795,0.0005272356,0.0002901288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003323779,"about_ca_system_score_gemma":0.0003555894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005019471,"about_ca_topic_score_gemma":0.000676351,"domain_scores_codex":[0.9998011,0.00004968916,0.00001815289,0.00006548337,0.00002627324,0.00003946534],"domain_scores_gemma":[0.9996903,0.00009874922,0.000121358,0.00002564108,0.00003058312,0.000033419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002112553,0.0002671683,0.4890963,0.004447402,0.001820615,0.003671213,0.000420364,0.004522094,0.2927097,0.005223912,0.00523081,0.1904777],"study_design_scores_gemma":[0.00009597562,0.0006429316,0.9225593,0.001057528,0.001095623,0.006582445,0.001328258,0.008570958,0.02104932,0.01441069,0.02249841,0.0001085211],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.836493,0.1284524,0.01659676,0.006856912,0.0002303322,0.00007917466,0.006649212,0.0002317556,0.004410448],"genre_scores_gemma":[0.9576117,0.0301603,0.007970244,0.0009775447,0.0002020539,0.00006880992,0.002302541,0.00003180429,0.0006748967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002760165,"threshold_uncertainty_score":0.009233713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969827767723359,"score_gpt":0.2844503054615946,"score_spread":0.264752027784361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}