{"id":"W3011243684","doi":"10.1016/j.isci.2020.100980","title":"Computation-Driven Analysis of Model Polyextremo-tolerant Fungus Exophiala dermatitidis: Defensive Pigment Metabolic Costs and Human Applications","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; Natural Sciences and Engineering Research Council of Canada; University of Nebraska-Lincoln","keywords":"Biology; Blastomyces dermatitidis; Melanin; Fungus; Systems biology; Yeast; Computational biology; Microbiology; Genetics; Botany; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005532172,0.0001043892,0.0001800566,0.00004407767,0.0001169219,0.00001970161,0.0001763891,0.00005441187,0.000005556265],"category_scores_gemma":[0.00002141422,0.00009628303,0.00007515735,0.0003392282,0.0001619256,0.000005559047,0.00009181556,0.00003413523,0.000001392114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005223116,"about_ca_system_score_gemma":0.0000410292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001636742,"about_ca_topic_score_gemma":0.00002113802,"domain_scores_codex":[0.9991999,0.00002112104,0.0001850142,0.0003242261,0.0001392118,0.0001305671],"domain_scores_gemma":[0.9995435,0.00001358651,0.0001060465,0.0001475341,0.00007785745,0.0001114974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000799499,0.00003189443,0.001372777,0.00001318418,0.0001121181,7.997086e-7,0.0001123848,0.007081442,0.9899005,0.000159073,0.00008003077,0.001127766],"study_design_scores_gemma":[0.0002146316,0.00005048515,0.008443498,0.00001058146,0.000455889,0.000006855394,0.0001953693,0.14713,0.8424647,0.00002990051,0.0007521865,0.00024593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655387,0.0008460328,0.03250627,0.0003333147,0.00000662148,0.0001389687,0.0002251278,0.000009326985,0.0003955708],"genre_scores_gemma":[0.9977459,0.00008709786,0.001577283,0.0003841383,0.00002994449,0.00001030002,0.000138381,0.000004020095,0.00002294684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1474359,"threshold_uncertainty_score":0.3926308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975392923615163,"score_gpt":0.2606685761874017,"score_spread":0.2409146469512501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}