{"id":"W3011243684","doi":"10.1016/j.isci.2020.100980","title":"Computation-Driven Analysis of Model Polyextremo-tolerant Fungus Exophiala dermatitidis: Defensive Pigment Metabolic Costs and Human Applications","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"University of Manitoba; Natural Sciences and Engineering Research Council of Canada; University of Nebraska-Lincoln","keywords":"Biology; Blastomyces dermatitidis; Melanin; Fungus; Systems biology; Yeast; Computational biology; Microbiology; Genetics; Botany; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774261,0.0003921915,0.0004105847,0.0003082258,0.0003446918,0.0005013678,0.0006212803,0.0006403652,0.003412765],"category_scores_gemma":[0.0008761508,0.0002033205,0.0005406659,0.0002058896,0.0003310368,0.000293893,0.0004046201,0.0004733981,0.0002214542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005519663,"about_ca_system_score_gemma":0.0007244387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01137493,"about_ca_topic_score_gemma":0.008844383,"domain_scores_codex":[0.9999282,0.00001528598,0.000003223165,0.00001735038,0.00001566793,0.0000203287],"domain_scores_gemma":[0.9995884,0.0002372851,0.00004220149,0.00002739742,0.00006779232,0.00003696322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00008137176,0.00005814147,0.003124265,0.00006371873,0.00002545741,0.0001464964,0.00002238548,0.984794,0.003761068,0.004431938,0.0007484621,0.00274282],"study_design_scores_gemma":[0.000005191455,0.000008079131,0.0003071213,0.000001499068,0.000002523342,0.00000685996,0.000007905923,0.9982865,0.0002868581,0.0009457735,0.0001398881,0.00000171563],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9234054,0.0004458354,0.06312939,0.0006948986,0.00005667328,0.00004282642,0.001455449,0.0005951338,0.01017442],"genre_scores_gemma":[0.9834936,0.0001121321,0.01329534,0.00005349803,0.00001041023,0.00004741611,0.0008086035,0.00008017514,0.002098904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01137493,"threshold_uncertainty_score":0.0226174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975392923615163,"score_gpt":0.2606685761874017,"score_spread":0.2409146469512501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}