{"id":"W3011295729","doi":"10.1080/14740338.2020.1744562","title":"An update on the safety of apremilast for the treatment of plaque psoriasis","year":2020,"lang":"en","type":"review","venue":"Expert Opinion on Drug Safety","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Apremilast; Medicine; Psoriasis; Adverse effect; Dermatology; Thalidomide; Drug; Intensive care medicine; Pharmacology; Psoriatic arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019973,0.0003478698,0.0006607677,0.00003426659,0.0001596922,0.00000983524,0.0003024238,0.0002142658,0.00004553932],"category_scores_gemma":[0.00003945655,0.0001699237,0.0006004343,0.00009982043,0.00009445979,0.000002900508,0.00003048682,0.00008143028,0.000007060828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006607196,"about_ca_system_score_gemma":0.0001355478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000100781,"about_ca_topic_score_gemma":0.000005120695,"domain_scores_codex":[0.998453,0.000247615,0.0005681133,0.0004145407,0.0001693638,0.0001474118],"domain_scores_gemma":[0.9984202,0.0002605124,0.0004229168,0.0007707641,0.0000663498,0.0000592203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001310764,0.0003195521,5.636412e-7,0.0002872011,0.0004477857,1.689536e-7,0.0003186954,0.0001231155,0.0001466061,0.001308485,0.01136513,0.984372],"study_design_scores_gemma":[0.0005653474,0.0008647799,0.000005722517,0.0005971497,0.00004254383,0.000001958461,0.00009509666,0.00006501079,0.004295409,0.000005667952,0.9932907,0.0001706765],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001084866,0.9933978,0.0009773738,0.001596903,0.001425465,0.001649985,0.0006560761,0.00001310829,0.0002723973],"genre_scores_gemma":[0.0002850019,0.9965742,0.00007201404,0.0002483469,0.0008067914,0.0002324346,0.001569276,0.00004216417,0.0001697604],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9842013,"threshold_uncertainty_score":0.6929288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03635905666218543,"score_gpt":0.3320589608878349,"score_spread":0.2956999042256495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}