{"id":"W3011315437","doi":"10.1038/s41467-020-15124-z","title":"Crystal structure of a lipin/Pah phosphatidic acid phosphatase","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"California NanoSystems Institute; Division of Chemistry; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; American Heart Association; National Science Foundation; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Michael Smith Health Research BC; U.S. Department of Health and Human Services; National Institutes of Health; State University of New York; Stony Brook University; Government of Canada","keywords":"Diacylglycerol kinase; Phosphatidic acid; Cell biology; Chemistry; Function (biology); Biochemistry; Phosphatase; Biology; Membrane; Signal transduction; Enzyme; Phospholipid; Protein kinase C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002792738,0.0004215478,0.0004283169,0.000177154,0.0008125261,0.000822589,0.0007211658,0.0005878172,0.004272221],"category_scores_gemma":[0.0004723927,0.0002571385,0.0001608814,0.0003522025,0.0002631457,0.0004324313,0.000338201,0.001764998,0.0007105705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165871,"about_ca_system_score_gemma":0.001043367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006800491,"about_ca_topic_score_gemma":0.008071431,"domain_scores_codex":[0.9998487,0.00001779086,0.000005096545,0.00003006835,0.00007060906,0.00002770924],"domain_scores_gemma":[0.9998312,0.00003430998,0.00001996217,0.000006683531,0.00004764833,0.00006024352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004017233,0.001831088,0.01964002,0.001503644,0.000646216,0.005286299,0.001240818,0.02477821,0.7826,0.01525207,0.08788394,0.05532043],"study_design_scores_gemma":[0.003540325,0.001742959,0.09877785,0.0004093306,0.0006546561,0.005564626,0.002537353,0.2758106,0.3217502,0.01054293,0.2783676,0.0003015565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476194,0.009720478,0.006606405,0.003625772,0.000601036,0.0001431688,0.006549966,0.0007921979,0.02434161],"genre_scores_gemma":[0.9470133,0.004741467,0.009567787,0.0007562383,0.00008304432,0.0001364007,0.0215934,0.0001865737,0.01592176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006800491,"threshold_uncertainty_score":0.014292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01145894616727112,"score_gpt":0.2556699851366447,"score_spread":0.2442110389693736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}