{"id":"W3011358496","doi":"10.21577/0103-5053.20200046","title":"New Synthetic Quinolines as Cathepsin K Inhibitors","year":2020,"lang":"en","type":"article","venue":"Journal of the Brazilian Chemical Society","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Chemistry; Combinatorial chemistry; Pharmacology; Computational biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001069103,0.0001263799,0.0001772284,0.000004210716,0.00005049782,0.00002468346,0.0004069189,0.0001258028,0.00004603509],"category_scores_gemma":[0.0004325748,0.00008143059,0.0006814728,0.0001044164,0.00009344039,0.000005934607,0.0001579777,0.0001808799,0.00001015041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001063545,"about_ca_system_score_gemma":0.0002173804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006555921,"about_ca_topic_score_gemma":3.374634e-7,"domain_scores_codex":[0.9991561,0.00003903167,0.0002770413,0.0001480818,0.0002192041,0.0001605536],"domain_scores_gemma":[0.9992455,0.00001612611,0.0001907934,0.0001806365,0.00007206499,0.0002948472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009178769,0.00003399931,0.0005341699,0.00001326456,0.00005506094,0.000001102899,0.0001449621,0.00000774556,0.8311641,0.00001057359,0.1667003,0.00124304],"study_design_scores_gemma":[0.0005362772,0.00005625869,0.0004572856,0.00002231894,0.00007871353,0.00004042923,0.0001204107,0.000009198658,0.8908436,0.000235592,0.1074828,0.0001170994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856332,0.002870564,0.0001249538,0.01082556,0.0002755309,0.00005969808,0.000007596893,0.00000625413,0.0001966683],"genre_scores_gemma":[0.9916298,0.0001825718,0.000990398,0.004521661,0.002295965,5.962829e-7,0.000002668665,0.00001828478,0.0003580441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05967961,"threshold_uncertainty_score":0.3320643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007418858958995786,"score_gpt":0.2298501114032933,"score_spread":0.2224312524442975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}