{"id":"W3011381142","doi":"10.1016/j.ekir.2020.02.913","title":"SUN-374 B-CELL DEPLETION AND RESPONSE IN A RANDOMIZED, CONTROLLED TRIAL OF OBINUTUZUMAB FOR PROLIFERATIVE LUPUS NEPHRITIS","year":2020,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Obinutuzumab; Medicine; Lupus nephritis; CD20; Belimumab; Monoclonal antibody; Monoclonal; Internal medicine; Immunology; B cell; Cancer research; Oncology; Antibody; B-cell activating factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002988689,0.0001590517,0.001340678,0.0002535472,0.00002482119,0.000028104,0.00007190326,0.0001102734,0.00008824254],"category_scores_gemma":[0.03921894,0.0001241105,0.0003144312,0.000125144,0.0001055384,0.00008955712,0.00005070332,0.0001531281,0.000002411348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002868102,"about_ca_system_score_gemma":0.001324026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005872972,"about_ca_topic_score_gemma":0.000004297065,"domain_scores_codex":[0.996969,0.0003977254,0.00135098,0.0003700347,0.0007297066,0.0001825461],"domain_scores_gemma":[0.9967757,0.001648263,0.0005813636,0.0001679515,0.0005435324,0.0002832246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9830126,0.0001440601,0.003392487,0.000231142,0.0002422387,0.0004017963,0.001726166,0.00000436343,0.006550113,0.0001558726,0.004088995,0.0000502129],"study_design_scores_gemma":[0.984718,0.0008433608,0.00003198515,0.0004196003,0.00009027265,0.00426246,0.0002535013,0.004257631,0.002198609,0.0003288545,0.002492591,0.0001031004],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762586,0.0002226623,0.0007086548,0.008562485,0.0008143961,0.01062088,0.00002613523,0.00002767499,0.002758512],"genre_scores_gemma":[0.9941814,0.00008764135,0.0006489018,0.0005635974,0.0002914514,0.00191038,0.00006332983,0.00002461282,0.002228716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03623025,"threshold_uncertainty_score":0.9688742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837310336821344,"score_gpt":0.3042281764120002,"score_spread":0.2858550730437868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}